BDBM50050467 1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperidin-4-ol::3-[4-(4-chlorophenyl)-4-hydroxypiperidinyl]methylindole::4-(4-Chloro-phenyl)-1-(1H-indol-3-ylmethyl)-piperidin-4-ol::CHEMBL445102::L-741626::L741,626

SMILES OC1(CCN(Cc2c[nH]c3ccccc23)CC1)c1ccc(Cl)cc1

InChI Key InChIKey=LLBLNMUONVVVPG-UHFFFAOYSA-N

Data  44 KI  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 48 hits for monomerid = 50050467   

TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataIC50: 4.46nMAssay Description:Antagonist activity at dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataIC50: 90.4nMAssay Description:Antagonist activity at dopamine D3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataEC50:  4.46nMAssay Description:Antagonist activity at human dopamine D2 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataEC50:  90.4nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity towards cloned human Dopamine receptor D2 stably expressed in CHO cells was evaluated using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  2.95nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  3.98nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
TargetD(2) dopamine receptor(Rat)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  6.31nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  6.61nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  7.5nMAssay Description:Displacement of [3H]methylspiperone from human D2L receptor expressed in HEK cell membrane after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]ABN from human dopamine D2 long receptor expressed in HEK293 cells after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  11.2nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  11.2nMAssay Description:Displacement of [125I]IABN from human dopamine D2L receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  11.2nMAssay Description:Displacement of [125I]IABN from human dopamine D2L receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Washington University

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  19.3nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain homogenates after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  49nMAssay Description:Displacement of [3H]methylspiperone from human D3 receptor expressed in HEK293 cell membrane after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  54nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  60nMAssay Description:Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  63.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  87nMAssay Description:Compound was measured for its ability to compete with [3H]spiperone binding to the human Dopamine receptor D3 transfected in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  87.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  100nMAssay Description:Binding affinity towards cloned human Dopamine receptor D3 stably expressed in CHO cells was evaluated using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  104nMAssay Description:Displacement of [125I]ABN from human dopamine D3 receptor expressed in HEK293 cells after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  163nMAssay Description:Displacement of [125I]IABN from human dopamine D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  163nMAssay Description:Displacement of [125I]IABN from human dopamine D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  220nMAssay Description:Binding affinity towards cloned human Dopamine receptor D4 stably expressed in CHO cells was evaluated using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  251nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  316nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  316nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  449nMAssay Description:Displacement of [125I]ABN from human dopamine D4 receptor expressed in HEK293 cells after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  631nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
TargetD(1B) dopamine receptor(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  631nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  695nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  722nMAssay Description:Displacement of [3H]SCH23390 from dopamine D1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
National Institute On Drug Abuses

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  794nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  1.10E+3nMAssay Description:Displacement of [125I]IABN from human dopamine D4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor [16-465](Rat)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  1.26E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  1.52E+3nMAssay Description:Displacement of [125I]IABN from human dopamine D4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  1.52E+3nMAssay Description:Displacement of [125I]DOI from human dopamine D4 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  3.98E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2C(Pig)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  3.98E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  6.30E+3nMAssay Description:Displacement of [3H]8OH-DPAT from 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50050467(L741,626 | CHEMBL445102 | 3-[4-(4-chlorophenyl)-4-...)
Affinity DataKi:  6.57E+3nMAssay Description:Displacement of [3H]mesulergine from 5HT2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed