BDBM50098937 (S)-methyl 2-amino-5-(amino(nitroamino)methyleneamino)pentanoate::CHEMBL1256014::CHEMBL7890::L-NAME::N(gamma)-Nitro-L-arginine methyl ester::N-.omega.-Nitro-O-arginine methyl ester::N-omega-nitro-L-arginine methyl ester::methyl (2S)-2-amino-5-{[(E)-imino(nitroamino)methyl]amino}pentanoate::methyl (2S)-2-amino-5-{[(Z)-imino(nitroamino)methyl]amino}pentanoate::nitro-L-arginine methyl ester

SMILES COC(=O)[C@@H](N)CCCNC(N)=N[N+]([O-])=O

InChI Key InChIKey=KCWZGJVSDFYRIX-UHFFFAOYSA-N

Data  1 KI  23 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50098937   

TargetNitric oxide synthase, endothelial(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibitory activity against human endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Rat)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 7.00E+4nMAssay Description:Inhibition of rat brain nNOS expressed in baculovirus-infected Sf9 cells Escherichia coli assessed as reduction of [3H]-arginine to [3H]-citrulline c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, inducible(Human)
University of Granada

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 1.35E+4nMAssay Description:Inhibition of iNOS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNitric oxide synthase, inducible(Human)
University of Granada

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 3.00E+8nMAssay Description:Inhibitory concentration against nitric oxide synthesis in intact DLD-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
National Formosa University

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 2.58E+4nMAssay Description:Inhibition of iNOS in mouse BV2 microglial cells assessed as NO productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
University of Granada

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 830nMAssay Description:Inhibition of human recombinant iNOS expressed in Sf9 cells assessed as inhibition of conversion of [3H]-L-arginine to [3H]-L-citrulline after 45 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2013
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 680nMAssay Description:Inhibition of human recombinant eNOS expressed in Sf9 cells assessed as inhibition of conversion of [3H]-L-arginine to [3H]-L-citrulline after 45 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2013
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 690nMAssay Description:Inhibition of human recombinant nNOS expressed in Sf9 cells assessed as inhibition of conversion of [3H]-L-arginine to [3H]-L-citrulline after 45 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2013
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
National Formosa University

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 2.58E+4nMAssay Description:Inhibition of iNOS-mediated NO production in LPS-induced mouse BV2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 150nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
University of Granada

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibitory activity of compound against human inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
University of Granada

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibitory concentration against nitric oxide synthesis in intact DLD-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
National Formosa University

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 2.60E+3nMAssay Description:Compound was tested for its inhibitory activity against macrophage NO2- synthesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Bovine)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound was tested for its inhibitory activity against endothelial NO2- synthesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibitory concentration against recombinant human Endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibitory concentration against recombinant human (neuronal nitric oxide synthase) n-NOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
University of Granada

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibitory concentration against human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
National Formosa University

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 1.34E+4nMAssay Description:Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse BV2 cells measured after 24 hrs of post-stimulation by Griess reaction me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 1.50E+3nMAssay Description:In vitro inhibition of endothelial nitric oxide synthase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 1.60E+3nMAssay Description:Concentration required to inhibit neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
University of Granada

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 8.00E+3nMAssay Description:In vitro inhibition of inducible nitric oxide synthase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 2.70E+3nMAssay Description:Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Rat)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 150nMAssay Description:Inhibition of conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by neuronal NOS (n NOS) from rat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
University of Granada

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataKi:  7.00E+4nMAssay Description:Inhibition of human iNOS assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed