BDBM50004051 2-Amino-4-phosphono-butyric acid::2-Amino-4-phosphono-butyric acid (AP4)::4-Amino Phosphonobutyrate::CHEMBL285843::GlcN-6-P synthase inhibitor, 1 (racemic mixture)::L-AP4

SMILES C(CP(=O)(O)O)[C@@H](C(=O)O)N

InChI Key InChIKey=DDOQBQRIEWHWBT-UHFFFAOYSA-N

Data  14 KI  2 IC50  3 EC50

PDB links: 3 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50004051   

TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL

LigandBDBM50004051(CHEMBL285843 | 2-Amino-4-phosphono-butyric acid | ...)Copy SMILESCopy InChI

Affinity DataIC50: 5.10nMAssay Description:Inhibitory concentration against [3H]1 binding to recombinant human Metabotropic glutamate receptor 8More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/2/2012
Entry Details Article
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TargetMetabotropic glutamate receptor 4(Human)
Georgetown University Medical Center

Curated by ChEMBL

LigandBDBM50004051(CHEMBL285843 | 2-Amino-4-phosphono-butyric acid | ...)Copy SMILESCopy InChI

Affinity DataEC50:  330nMAssay Description:Compound was tested for the inhibition of Metabotropic glutamate receptor 4More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
11/7/2012
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TargetMetabotropic glutamate receptor 6(Human)
Georgetown University Medical Center

Curated by ChEMBL

LigandBDBM50004051(CHEMBL285843 | 2-Amino-4-phosphono-butyric acid | ...)Copy SMILESCopy InChI

Affinity DataEC50:  280nMAssay Description:Compound was tested for the inhibition of Metabotropic glutamate receptor 6More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
11/7/2012
Entry Details Article
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TargetMetabotropic glutamate receptor 6(Rat)
TBA

Curated by ChEMBL

LigandBDBM50004051(CHEMBL285843 | 2-Amino-4-phosphono-butyric acid | ...)Copy SMILESCopy InChI

Affinity DataEC50:  1.00E+3nMAssay Description:Tested for the agonistic activity against Metabotropic glutamate receptor 6More data for this Ligand-Target Pair

Target InfoUniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
8/22/2010
Entry Details Article
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TargetMetabotropic glutamate receptor 6(Rat)
TBA

Curated by ChEMBL

LigandBDBM50004051(CHEMBL285843 | 2-Amino-4-phosphono-butyric acid | ...)Copy SMILESCopy InChI

Affinity DataKi:  398nMMore data for this Ligand-Target Pair

Target InfoUniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
5/25/2012
Entry Details Article
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TargetMetabotropic glutamate receptor 4(Rat)
Case Western Reserve University

Curated by PDSP K_i Database

LigandBDBM50004051(CHEMBL285843 | 2-Amino-4-phosphono-butyric acid | ...)Copy SMILESCopy InChI

Affinity DataKi:  398nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
5/25/2012
Entry Details Article
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TargetMetabotropic glutamate receptor 4(Human)
Georgetown University Medical Center

Curated by ChEMBL

LigandBDBM50004051(CHEMBL285843 | 2-Amino-4-phosphono-butyric acid | ...)Copy SMILESCopy InChI

Affinity DataKi:  400nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/25/2012
Entry Details Article
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TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL

LigandBDBM50004051(CHEMBL285843 | 2-Amino-4-phosphono-butyric acid | ...)Copy SMILESCopy InChI

Affinity DataKi:  400nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/25/2012
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetMetabotropic glutamate receptor 4(Rat)
Case Western Reserve University

Curated by PDSP K_i Database

LigandBDBM50004051(CHEMBL285843 | 2-Amino-4-phosphono-butyric acid | ...)Copy SMILESCopy InChI

Affinity DataKi:  400nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/24/2012
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP K_i Database

LigandBDBM50004051(CHEMBL285843 | 2-Amino-4-phosphono-butyric acid | ...)Copy SMILESCopy InChI

Affinity DataKi:  680nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
3/28/2012
Entry Details Article
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TargetMetabotropic glutamate receptor 6(Human)
Georgetown University Medical Center

Curated by ChEMBL

LigandBDBM50004051(CHEMBL285843 | 2-Amino-4-phosphono-butyric acid | ...)Copy SMILESCopy InChI

Affinity DataKi:  900nMMore data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/25/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetMetabotropic glutamate receptor 8(Rat)
Case Western Reserve University

Curated by PDSP K_i Database

LigandBDBM50004051(CHEMBL285843 | 2-Amino-4-phosphono-butyric acid | ...)Copy SMILESCopy InChI

Affinity DataKi:  1.26E+3nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
5/25/2012
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetGlutamate receptor 3(Rat)
Eli Lilly

Curated by PDSP K_i Database

LigandBDBM50004051(CHEMBL285843 | 2-Amino-4-phosphono-butyric acid | ...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
5/2/2012
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by PDSP K_i Database

LigandBDBM50004051(CHEMBL285843 | 2-Amino-4-phosphono-butyric acid | ...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
4/24/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetMetabotropic glutamate receptor 1(Human)
F. Hoffmann-La Roche

Curated by PDSP K_i Database

LigandBDBM50004051(CHEMBL285843 | 2-Amino-4-phosphono-butyric acid | ...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
4/24/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP K_i Database

LigandBDBM50004051(CHEMBL285843 | 2-Amino-4-phosphono-butyric acid | ...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
3/3/2012
Entry Details
Copy Entry DOIPubMed
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TargetMetabotropic glutamate receptor 7(Human)
Emory University

Curated by PDSP K_i Database

LigandBDBM50004051(CHEMBL285843 | 2-Amino-4-phosphono-butyric acid | ...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/25/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetGlutamine--fructose-6-phosphate aminotransferase [isomerizing](Yeast)
Technical University of Gdansk

LigandBDBM50004051(CHEMBL285843 | 2-Amino-4-phosphono-butyric acid | ...)Copy SMILESCopy InChI

Affinity DataKi:  1.20E+7nM IC50: 2.60E+7nMpH: 6.85Assay Description:Two assays of GlcN-6-P synthase activity were used 1)determination of GlcN-6_P formation by the modified Elson-Morgan procedure and 2) continuous qua...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
3/19/2012
Entry Details
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