BDBM50594971 15-AU-81::15AU81::CHEBI:50861::L-606::LRX -15::LRX-15::Remodulin::Rumodolin::TREPROSTINIL::Treprostinil::Tresprostinil::Tyvaso::Tyvaso dpi::UT-15::Uniprost

SMILES CCCCC[C@@H](CC[C@@H]1[C@H]2Cc3cccc(c3C[C@H]2C[C@H]1O)OCC(=O)O)O

InChI Key InChIKey=PAJMKGZZBBTTOY-UHFFFAOYSA-N

Data  4 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50594971   

TargetProstaglandin D2 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50594971(TREPROSTINIL | CHEBI:50861 | Treprostinil | Trespr...)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at human DP1 expressed in human 1321N1 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProstacyclin receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50594971(TREPROSTINIL | CHEBI:50861 | Treprostinil | Trespr...)
Affinity DataEC50:  1.90nMAssay Description:Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin E2 receptor EP2 subtype(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50594971(TREPROSTINIL | CHEBI:50861 | Treprostinil | Trespr...)
Affinity DataEC50:  6.20nMAssay Description:Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50594971(TREPROSTINIL | CHEBI:50861 | Treprostinil | Trespr...)
Affinity DataEC50:  285nMAssay Description:Agonist activity at human EP1 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed