BDBM50067797 CHEMBL19080::L-37378::N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methyl-2-oxo-3-phenethylamino-2H-pyrazin-1-yl)-acetamide::US11584714, Compound 1488::US12195427, Compound 1488

SMILES Cc1nc(N)ccc1CNC(=O)Cn1c(C)cnc(NCCc2ccccc2)c1=O

InChI Key InChIKey=PVDHYBJORRALSQ-UHFFFAOYSA-N

Data  22 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50067797   

TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi:  0.800nMAssay Description:Inhibitory activity against thrombin (IIa) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of thrombin in human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi:  0.800nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi:  0.800nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of Thrombin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi:  0.800nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human thrombin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi:  1nMAssay Description:In vitro inhibitory constant against human thrombin (FIIa).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi:  1nMAssay Description:In vitro inhibitory activity against human Thrombin (FIIa) cleavage of the chromogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi: <500nMAssay Description:The thrombin assay utilizes a fluorogenic peptide substrate (Boc-VPR-AMC (R&D Systems) and was run at room temperature in an assay buffer containing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetMannan-binding lectin serine protease 2(Human)
Omeros

US Patent
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi: <500nMAssay Description:The MASP-2 assay protocol was carried out as follows. Test compounds were serially diluted in DMSO and then 100 nL of each dilution was transferred t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi: <500nMAssay Description:The thrombin assay utilizes a fluorogenic peptide substrate (Boc-VPR-AMC (R&D Systems) and was run at room temperature in an assay buffer containing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
Go to US Patent

TargetMannan-binding lectin serine protease 2(Human)
Omeros

US Patent
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
Go to US Patent

TargetTrypsin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibition of human trypsin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTrypsin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibition of trypsin in human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibition of TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibitory constant against human trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibitory activity against trypsin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMannan-binding lectin serine protease 2(Mouse)
Omeros

US Patent
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi:  6.25E+3nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
Go to US Patent

TargetMannan-binding lectin serine protease 2(Mouse)
Omeros

US Patent
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi:  6.25E+3nMAssay Description:The MASP-2 assay protocol was carried out as follows. Test compounds were serially diluted in DMSO and then 100 nL of each dilution was transferred t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent