BDBM50059376 9-Methyl-2-phenyl-5,9-dihydro-[1,2,4]triazolo[5,1-a][2,7]naphthyridine-6-carboxylic acid methyl ester::CHEMBL52735::L-249313

SMILES COC(=O)C1=C2C=CN(C)C=C2c2nc(nn2C1)-c1ccccc1

InChI Key InChIKey=DBROFPXBIMMIMF-UHFFFAOYSA-N

Data  8 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50059376   

TargetAdenosine receptor A2b(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50059376(L-249313 | 9-Methyl-2-phenyl-5,9-dihydro-[1,2,4]tr...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50059376(L-249313 | 9-Methyl-2-phenyl-5,9-dihydro-[1,2,4]tr...)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibitory activity against cyclic AMP production in human Adenosine A1 receptor assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50059376(L-249313 | 9-Methyl-2-phenyl-5,9-dihydro-[1,2,4]tr...)
Affinity DataIC50: 2.75E+4nMAssay Description:Inhibitory activity against cyclic AMP production in rat Adenosine A2A receptor assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50059376(L-249313 | 9-Methyl-2-phenyl-5,9-dihydro-[1,2,4]tr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against cyclic AMP production in human Adenosine A2B receptor assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50059376(L-249313 | 9-Methyl-2-phenyl-5,9-dihydro-[1,2,4]tr...)
Affinity DataKi:  13nMAssay Description:Displacement of specific [125I]AB-MECA binding at human adenosine A3 receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50059376(L-249313 | 9-Methyl-2-phenyl-5,9-dihydro-[1,2,4]tr...)
Affinity DataKi:  13nMAssay Description:Displacement of [125I]ABA from human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50059376(L-249313 | 9-Methyl-2-phenyl-5,9-dihydro-[1,2,4]tr...)
Affinity DataKi:  13nMAssay Description:Inhibition of [35S]GTP-gamma-S, binding stimulated by 20 uM 5''-N-ethyluronamidoadenosine (NECA) in membranes of HEK293 cells expressing human Adenos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50059376(L-249313 | 9-Methyl-2-phenyl-5,9-dihydro-[1,2,4]tr...)
Affinity DataKi:  13nMAssay Description:Binding affinity towards adenosine A3 receptor expressed in HEK293 cells versus [125I]AB-MECAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50059376(L-249313 | 9-Methyl-2-phenyl-5,9-dihydro-[1,2,4]tr...)
Affinity DataKi:  170nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50059376(L-249313 | 9-Methyl-2-phenyl-5,9-dihydro-[1,2,4]tr...)
Affinity DataKi:  172nMAssay Description:Displacement of specific [125I]AB-MECA binding at human adenosine A3 receptor expressed in HEK 293 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50059376(L-249313 | 9-Methyl-2-phenyl-5,9-dihydro-[1,2,4]tr...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding Affinity for adenosine A2A receptor expressed in HEK293 cells compared to [3H]CGS-21680More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50059376(L-249313 | 9-Methyl-2-phenyl-5,9-dihydro-[1,2,4]tr...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding Affinity towards Adenosine A1 receptor expressed in CHO-K1 cells versus [3H]CCPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed