BDBM50247930 Dexilant::Dexilant solutab::Dexlansoprazole::Kapidex::T-168390::TAK-390

SMILES Cc1c(OCC(F)(F)F)ccnc1C[S@@+]([O-])c1nc2ccccc2[nH]1

InChI Key InChIKey=MJIHNNLFOKEZEW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50247930   

LigandPNGBDBM50247930(Dexilant | Dexilant solutab | Dexlansoprazole | Ka...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50247930(Dexilant | Dexilant solutab | Dexlansoprazole | Ka...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50247930(Dexilant | Dexilant solutab | Dexlansoprazole | Ka...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50247930(Dexilant | Dexilant solutab | Dexlansoprazole | Ka...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetCytosolic endo-beta-N-acetylglucosaminidase(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50247930(Dexilant | Dexilant solutab | Dexlansoprazole | Ka...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of recombinant human C-MYC/DDK-tagged ENGase expressed in HEK293T cells using heat inactivated bovine ribonuclease B as substrate pretreat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2019
Entry Details Article
PubMed