BDBM50197240 CHEMBL248088::KYS-05080::N-Benzyl-2-{3-biphenyl-4-yl-2-[methyl-(5-pyrrolidin-1-yl-pentyl)-amino]-3,4-dihydro-quinazolin-4-yl}-acetamide::N-benzyl-2-(3-(biphenyl-4-yl)-2-(methyl(5-(pyrrolidin-1-yl)pentyl)amino)-3,4-dihydroquinazolin-4-yl)acetamide

SMILES CN(CCCCCN1CCCC1)C1=Nc2ccccc2C(CC(=O)NCc2ccccc2)N1c1ccc(cc1)-c1ccccc1

InChI Key InChIKey=SXLKSZQOUGOJGV-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50197240   

TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50197240(KYS-05080 | N-benzyl-2-(3-(biphenyl-4-yl)-2-(methy...)
Affinity DataIC50: 260nMAssay Description:Inhibition of human T-type calcium channel alpha1G in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50197240(KYS-05080 | N-benzyl-2-(3-(biphenyl-4-yl)-2-(methy...)
Affinity DataIC50: 260nMAssay Description:Inhibition of T-type calcium channel Cav3.1 expressed in HEK293 cells co-expressing alpha1G subunit by whole-cell patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50197240(KYS-05080 | N-benzyl-2-(3-(biphenyl-4-yl)-2-(methy...)
Affinity DataIC50: 260nMAssay Description:Inhibition of T-type calcium channel Cav3.1 alpha1G expressed in HEK293 cells by whole cell patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50197240(KYS-05080 | N-benzyl-2-(3-(biphenyl-4-yl)-2-(methy...)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured for 5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2019
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50197240(KYS-05080 | N-benzyl-2-(3-(biphenyl-4-yl)-2-(methy...)
Affinity DataIC50: 45nMAssay Description:Inhibition of equine serum BCHE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured for 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2019
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50197240(KYS-05080 | N-benzyl-2-(3-(biphenyl-4-yl)-2-(methy...)
Affinity DataKi:  29nMAssay Description:Mixed/noncompetitive inhibition of equine serum BCHE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2019
Entry Details Article
PubMed