BDBM223317 KDOAM-1

SMILES OC(=O)c1ccnc(CN2CCNCC2)c1

InChI Key InChIKey=VRQYPXABZCTNAE-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 223317   

TargetLysine-specific demethylase 5C(Human)
University of Oxford

LigandPNGBDBM223317(KDOAM-1)
Affinity DataIC50: 980nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4C(Human)
University of Oxford

LigandPNGBDBM223317(KDOAM-1)
Affinity DataIC50: 1.30E+3nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 5C(Human)
University of Oxford

LigandPNGBDBM223317(KDOAM-1)
Affinity DataIC50: 1.00E+3nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 3A(Human)
University of Oxford

LigandPNGBDBM223317(KDOAM-1)
Affinity DataIC50: 1.00E+5nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4C(Human)
University of Oxford

LigandPNGBDBM223317(KDOAM-1)
Affinity DataIC50: 1.00E+3nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4E(Human)
University of Oxford

LigandPNGBDBM223317(KDOAM-1)
Affinity DataIC50: 1.00E+4nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 6B(Human)
University of Oxford

LigandPNGBDBM223317(KDOAM-1)
Affinity DataIC50: 1.00E+5nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 2A(Human)
University of Oxford

LigandPNGBDBM223317(KDOAM-1)
Affinity DataIC50: 5.00E+4nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4C(Human)
University of Oxford

LigandPNGBDBM223317(KDOAM-1)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of KDM4C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetLysine-specific demethylase 5C(Human)
University of Oxford

LigandPNGBDBM223317(KDOAM-1)
Affinity DataIC50: 980nMAssay Description:Inhibition of KDM5C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed