BDBM50590370 K-0706::K0706::Sco-088::VODOBATINIB::Vodobatinib

SMILES Cc1ccc(cc1C#Cc1cnc2ccccc2c1)C(=O)NNC(=O)c1c(C)cccc1Cl

InChI Key InChIKey=ZQOBVMHBVWNVBG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50590370   

TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50590370(Vodobatinib | K-0706 | K0706 | Sco-088 | VODOBATIN...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of wild type BCR-ABL phosphorylation in mouse BaF3 cells incubated for 4 hrs by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetBCR/ABL1(Mouse)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50590370(Vodobatinib | K-0706 | K0706 | Sco-088 | VODOBATIN...)
Affinity DataIC50: 165nMAssay Description:Inhibition of BCR-ABL E255V mutant phosphorylation in mouse BaF3 cells incubated for 4 hrs by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetBreakpoint cluster region protein(Mouse)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50590370(Vodobatinib | K-0706 | K0706 | Sco-088 | VODOBATIN...)
Affinity DataIC50: 1.97E+3nMAssay Description:Inhibition of BCR-ABL T315I mutant phosphorylation in mouse BaF3 cells incubated for 4 hrs by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed