BDBM50589874 JYQ88

SMILES [N-]=[N+]=NCC(=O)N1CCc2nc(NC(=O)[C@@H]3CCN(C3)C#N)sc2C1

InChI Key InChIKey=KIWKRCCIHSGWQS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50589874   

TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Human)
Leiden University Medical Center

Curated by ChEMBL
LigandPNGBDBM50589874(JYQ88)
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibition of UCHL1 (unknown origin) using Ub-AMC as substrate preincubated with enzyme for 1 hr followed by substrate addition and measured for 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Human)
Leiden University Medical Center

Curated by ChEMBL
LigandPNGBDBM50589874(JYQ88)
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibition of UCHL1 (unknown origin) using Ub-Rho-Morpholine as substrate preincubated with enzyme for 1 hr followed by substrate addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetParkinson disease protein 7(Human)
Leiden University Medical Center

Curated by ChEMBL
LigandPNGBDBM50589874(JYQ88)
Affinity DataIC50: 130nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant PARK7 expressed in Escherichia coli BL21(DE3)Rosetta2 cells using DiFMUAc as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetParkinson disease protein 7(Human)
Leiden University Medical Center

Curated by ChEMBL
LigandPNGBDBM50589874(JYQ88)
Affinity DataIC50: 240nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant PARK7 expressed in Escherichia coli BL21(DE3)Rosetta2 cells assessed as reduction in JQ-107-lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed