BDBM21282 2-methyl-3-(naphthalen-1-ylcarbonyl)-1-propyl-1H-indole::CHEMBL306764::JWH-015

SMILES CCCn1c(C)c(C(=O)c2cccc3ccccc23)c2ccccc12

InChI Key InChIKey=LJSBBBWQTLXQEN-UHFFFAOYSA-N

Data  17 KI  1 IC50  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 21282   

TargetCannabinoid receptor 2(Mouse)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM21282(CHEMBL306764 | 2-methyl-3-(naphthalen-1-ylcarbonyl...)
Affinity DataEC50:  30nMAssay Description:Inverse agonist activity at mouse CB2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Mouse)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM21282(CHEMBL306764 | 2-methyl-3-(naphthalen-1-ylcarbonyl...)
Affinity DataEC50:  160nMAssay Description:Inverse agonist activity at C-terminally prolink-tagged mouse CB2 receptor expressed in CHOK1 cells harboring beta-galactosidase enzyme fused beta-ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
City of Hope National Medical Center

Curated by ChEMBL
LigandPNGBDBM21282(CHEMBL306764 | 2-methyl-3-(naphthalen-1-ylcarbonyl...)
Affinity DataIC50: 3.22E+3nMAssay Description:Antagonist activity at human GTS-tagged FXR after 20 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
City of Hope National Medical Center

Curated by ChEMBL
LigandPNGBDBM21282(CHEMBL306764 | 2-methyl-3-(naphthalen-1-ylcarbonyl...)
Affinity DataEC50:  2.64E+3nMAssay Description:Agonist activity at PXR (unknown origin) expressed in human HepG2 cells assessed as induction of CYP3A4 transactivation after 16 hrs by luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM21282(CHEMBL306764 | 2-methyl-3-(naphthalen-1-ylcarbonyl...)
Affinity DataEC50:  634nMAssay Description:Agonist activity at human recombinant CB2 receptor expressed in HEK293 cells coexpressing Galphaq/o5 assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM21282(CHEMBL306764 | 2-methyl-3-(naphthalen-1-ylcarbonyl...)
Affinity DataKi:  13.3nMAssay Description:Displacement of [3H]CP 55940 from human CB2 receptor in cell free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM21282(CHEMBL306764 | 2-methyl-3-(naphthalen-1-ylcarbonyl...)
Affinity DataKi:  13.8nMAssay Description:Displacement of [3H]CP-55940 from human cloned CB2 receptor by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM21282(CHEMBL306764 | 2-methyl-3-(naphthalen-1-ylcarbonyl...)
Affinity DataKi:  14nMAssay Description:Binding affinity to CB2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM21282(CHEMBL306764 | 2-methyl-3-(naphthalen-1-ylcarbonyl...)
Affinity DataKi:  14nMAssay Description:Binding affinity towards cloned human cannabinoid receptor 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM21282(CHEMBL306764 | 2-methyl-3-(naphthalen-1-ylcarbonyl...)
Affinity DataKi:  35nMAssay Description:Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM21282(CHEMBL306764 | 2-methyl-3-(naphthalen-1-ylcarbonyl...)
Affinity DataKi:  35nM EC50:  798nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM21282(CHEMBL306764 | 2-methyl-3-(naphthalen-1-ylcarbonyl...)
Affinity DataKi:  36nMAssay Description:In vitro inhibitory activity towards human cannabinoid receptors 2 using fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM21282(CHEMBL306764 | 2-methyl-3-(naphthalen-1-ylcarbonyl...)
Affinity DataKi:  98.4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details
PubMed
TargetCannabinoid receptor 1/2(Human)TBA
LigandPNGBDBM21282(CHEMBL306764 | 2-methyl-3-(naphthalen-1-ylcarbonyl...)
Affinity DataKi:  164nMAssay Description:Binding affinity was determined in vitro against cannabinoid receptor by ability to displace [3H]CP-55940More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2020
Entry Details Article

TargetCannabinoid receptor 1(Rat)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM21282(CHEMBL306764 | 2-methyl-3-(naphthalen-1-ylcarbonyl...)
Affinity DataKi:  164nMAssay Description:Displacement of [3H]CP-55940 from CB1 receptor in rat brain by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Rat)
Virginia Commonwealth University

Curated by PDSP Ki Database
LigandPNGBDBM21282(CHEMBL306764 | 2-methyl-3-(naphthalen-1-ylcarbonyl...)
Affinity DataKi:  269nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details
PubMed
TargetCannabinoid receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM21282(CHEMBL306764 | 2-methyl-3-(naphthalen-1-ylcarbonyl...)
Affinity DataKi:  380nMAssay Description:Binding affinity towards cloned human Cannabinoid receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM21282(CHEMBL306764 | 2-methyl-3-(naphthalen-1-ylcarbonyl...)
Affinity DataKi:  383nMAssay Description:Binding affinity to CB1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM21282(CHEMBL306764 | 2-methyl-3-(naphthalen-1-ylcarbonyl...)
Affinity DataKi:  383nMAssay Description:Displacement of [3H]CP 55940 from human CB1 receptor in cell free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Mouse)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM21282(CHEMBL306764 | 2-methyl-3-(naphthalen-1-ylcarbonyl...)
Affinity DataKi:  431nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details
PubMed
TargetCannabinoid receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM21282(CHEMBL306764 | 2-methyl-3-(naphthalen-1-ylcarbonyl...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM21282(CHEMBL306764 | 2-methyl-3-(naphthalen-1-ylcarbonyl...)
Affinity DataKi:  1.20E+3nM ΔG°:  -8.20kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed