BDBM50083230 1-((3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-piperidin-4-yl)-3-ethyl-1,3-dihydro-benzoimidazol-2-one::1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one::1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one::CHEMBL357076::J-113397

SMILES CCn1c2ccccc2n([C@@H]2CCN(CC3CCCCCCC3)C[C@H]2CO)c1=O

InChI Key InChIKey=MBGVUMXBUGIIBQ-UHFFFAOYSA-N

Data  9 KI  11 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50083230   

TargetNociceptin receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083230(CHEMBL357076 | J-113397 | 1-((3R,4R)-1-Cyclooctylm...)
Affinity DataIC50: 2.30nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human cloned ORL1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083230(CHEMBL357076 | J-113397 | 1-((3R,4R)-1-Cyclooctylm...)
Affinity DataIC50: 3.40E+3nMAssay Description:Displacement of [3H]diprenorphin from cloned human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083230(CHEMBL357076 | J-113397 | 1-((3R,4R)-1-Cyclooctylm...)
Affinity DataIC50: 1.60E+3nMAssay Description:Displacement of [3H]U-69593 from cloned human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083230(CHEMBL357076 | J-113397 | 1-((3R,4R)-1-Cyclooctylm...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity in CHO cells stably expressing cloned human Opioid receptor delta 1 by displacing radioligand [3H][D-Ala2,D-Leu5]enkephalinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083230(CHEMBL357076 | J-113397 | 1-((3R,4R)-1-Cyclooctylm...)
Affinity DataIC50: 2.30nMAssay Description:Binding affinity in CHO cells stably expressing cloned human Opioid receptor like 1 by displacing radioligand [125I]Tyr14-nociceptinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083230(CHEMBL357076 | J-113397 | 1-((3R,4R)-1-Cyclooctylm...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonistic activity against nociceptin produced GTPgammaS binding to Opioid receptor like 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083230(CHEMBL357076 | J-113397 | 1-((3R,4R)-1-Cyclooctylm...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]naltrindole from cloned human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083230(CHEMBL357076 | J-113397 | 1-((3R,4R)-1-Cyclooctylm...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity on nociceptin-induced maximal [35S]GTP-gamma-S binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083230(CHEMBL357076 | J-113397 | 1-((3R,4R)-1-Cyclooctylm...)
Affinity DataIC50: 2.40nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083230(CHEMBL357076 | J-113397 | 1-((3R,4R)-1-Cyclooctylm...)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of [125I]Tyr14-nociceptin binding to human Opioid receptor like 1 (opioid receptor like 1) in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083230(CHEMBL357076 | J-113397 | 1-((3R,4R)-1-Cyclooctylm...)
Affinity DataIC50: 1.40E+3nMAssay Description:Binding affinity of the compound in CHO cells stably expressing cloned human Opioid receptor kappa 1 by displacing radioligand [3H]-U-69,593More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083230(CHEMBL357076 | J-113397 | 1-((3R,4R)-1-Cyclooctylm...)
Affinity DataIC50: 2.20E+3nMAssay Description:Binding affinity in CHO cells stably expressing cloned human Opioid receptor mu 1 by displacing diprenorphineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083230(CHEMBL357076 | J-113397 | 1-((3R,4R)-1-Cyclooctylm...)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity on nociceptin-induced [35S]GTP-gamma-S binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083230(CHEMBL357076 | J-113397 | 1-((3R,4R)-1-Cyclooctylm...)
Affinity DataKi:  0.403nMAssay Description:Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083230(CHEMBL357076 | J-113397 | 1-((3R,4R)-1-Cyclooctylm...)
Affinity DataKi:  1.51nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083230(CHEMBL357076 | J-113397 | 1-((3R,4R)-1-Cyclooctylm...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity towards Nociceptin/orphanin FQ (N/OFQ) receptor from recombinant HEK293 cell membranes was determined using binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083230(CHEMBL357076 | J-113397 | 1-((3R,4R)-1-Cyclooctylm...)
Affinity DataKi:  214nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083230(CHEMBL357076 | J-113397 | 1-((3R,4R)-1-Cyclooctylm...)
Affinity DataKi:  229nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083230(CHEMBL357076 | J-113397 | 1-((3R,4R)-1-Cyclooctylm...)
Affinity DataKi: >400nMAssay Description:Displacement of [3H]diprenorphine from human cloned delta type opioid receptor expressed in CHO cell membranes by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083230(CHEMBL357076 | J-113397 | 1-((3R,4R)-1-Cyclooctylm...)
Affinity DataKi: >400nMAssay Description:Displacement of [3H]diprenorphine from human cloned mu type opioid receptor expressed in CHO cell membranes by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083230(CHEMBL357076 | J-113397 | 1-((3R,4R)-1-Cyclooctylm...)
Affinity DataKi: >400nMAssay Description:Displacement of [3H]diprenorphine from human cloned kappa type opioid receptor expressed in CHO cell membranes by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50083230(CHEMBL357076 | J-113397 | 1-((3R,4R)-1-Cyclooctylm...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2012
Entry Details Article
PubMed