BDBM50020232 1-(2-{4-[(1R,3S)-3-(4-Fluoro-phenyl)-indan-1-yl]-piperazin-1-yl}-ethyl)-imidazolidin-2-one::1-(2-{4-[3-(4-Fluoro-phenyl)-indan-1-yl]-piperazin-1-yl}-ethyl)-imidazolidin-2-one::1-(2-{4-[3-(4-Fluoro-phenyl)-indan-1-yl]-piperazin-1-yl}-ethyl)-imidazolidin-2-one(Irindalone)::CHEMBL73461::Irindalone

SMILES Fc1ccc(cc1)[C@@H]1C[C@@H](N2CCN(CCN3CCNC3=O)CC2)c2ccccc12

InChI Key InChIKey=GHAMYXPEZSUOCU-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50020232   

TargetTransporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50020232(1-(2-{4-[3-(4-Fluoro-phenyl)-indan-1-yl]-piperazin...)
Affinity DataIC50: 44nMAssay Description:In vitro inhibition of [3H]norepinephrine uptake in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50020232(1-(2-{4-[3-(4-Fluoro-phenyl)-indan-1-yl]-piperazin...)
Affinity DataIC50: 100nMAssay Description:In vitro inhibition of [3H]dopamine uptake in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50020232(1-(2-{4-[3-(4-Fluoro-phenyl)-indan-1-yl]-piperazin...)
Affinity DataIC50: 1.40E+4nMAssay Description:In vitro inhibition of [3H]5-HT transporter uptake in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50020232(1-(2-{4-[3-(4-Fluoro-phenyl)-indan-1-yl]-piperazin...)
Affinity DataIC50: 400nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50020232(1-(2-{4-[3-(4-Fluoro-phenyl)-indan-1-yl]-piperazin...)
Affinity DataIC50: 400nMAssay Description:Binding affinity at dopamine D2 receptor by [3H]spiperone displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50020232(1-(2-{4-[3-(4-Fluoro-phenyl)-indan-1-yl]-piperazin...)
Affinity DataIC50: 400nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50020232(1-(2-{4-[3-(4-Fluoro-phenyl)-indan-1-yl]-piperazin...)
Affinity DataIC50: 2.50E+4nMAssay Description:In vitro inhibition of [3H]dopamine uptake in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50020232(1-(2-{4-[3-(4-Fluoro-phenyl)-indan-1-yl]-piperazin...)
Affinity DataIC50: 400nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
LigandPNGBDBM50020232(1-(2-{4-[3-(4-Fluoro-phenyl)-indan-1-yl]-piperazin...)
Affinity DataIC50: 26nMAssay Description:Inhibition of [3H]prazosin binding to alpha-1 adrenergic receptor from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
LigandPNGBDBM50020232(1-(2-{4-[3-(4-Fluoro-phenyl)-indan-1-yl]-piperazin...)
Affinity DataIC50: 26nMAssay Description:Inhibition of [3H]prazosin binding to alpha-1 adrenergic receptor from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50020232(1-(2-{4-[3-(4-Fluoro-phenyl)-indan-1-yl]-piperazin...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of [3H]spiperone binding to 5-hydroxytryptamine 2 receptor from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50020232(1-(2-{4-[3-(4-Fluoro-phenyl)-indan-1-yl]-piperazin...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of [3H]spiperone binding to 5-hydroxytryptamine 2 receptor from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50020232(1-(2-{4-[3-(4-Fluoro-phenyl)-indan-1-yl]-piperazin...)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro inhibition of [3H]5-HT transporter uptake in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50020232(1-(2-{4-[3-(4-Fluoro-phenyl)-indan-1-yl]-piperazin...)
Affinity DataIC50: 2.20E+4nMAssay Description:In vitro inhibition of [3H]norepinephrine uptake in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50020232(1-(2-{4-[3-(4-Fluoro-phenyl)-indan-1-yl]-piperazin...)
Affinity DataIC50: 3.40nMAssay Description:Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50020232(1-(2-{4-[3-(4-Fluoro-phenyl)-indan-1-yl]-piperazin...)
Affinity DataIC50: 2.60nMAssay Description:Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed