BDBM50229666 (2S,3S)-2-((S)-1-((2S,3S)-2-amino-3-methylpentanoyl)pyrrolidine-5-carboxamido)-3-methylpentanoic acid::CHEMBL214381::Ile-Pro-Ile

SMILES CC[C@H](C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(O)=O

InChI Key InChIKey=JNTMAZFVYNDPLB-UHFFFAOYSA-N

Data  3 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50229666   

TargetDipeptidyl peptidase 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50229666(Ile-Pro-Ile | (2S,3S)-2-((S)-1-((2S,3S)-2-amino-3-...)
Affinity DataIC50: 2.53E+3nMAssay Description:Inhibition of DPP4 in human plasma using Gly-Pro-AMC substrate incubated for 20 mins by fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Pig)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50229666(Ile-Pro-Ile | (2S,3S)-2-((S)-1-((2S,3S)-2-amino-3-...)
Affinity DataIC50: 1.44E+4nMAssay Description:Inhibition of pig DPP4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50229666(Ile-Pro-Ile | (2S,3S)-2-((S)-1-((2S,3S)-2-amino-3-...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human recombinant DPP4 assessed as Gly-Pro-pNA chromogenic substrate cleavage for 16 mins preincubated with compound for 10 mins before...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50229666(Ile-Pro-Ile | (2S,3S)-2-((S)-1-((2S,3S)-2-amino-3-...)
Affinity DataIC50: 4.21E+3nMAssay Description:Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 4 secs followed by substrate addition and measured after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50229666(Ile-Pro-Ile | (2S,3S)-2-((S)-1-((2S,3S)-2-amino-3-...)
Affinity DataKi:  2.20E+3nMAssay Description:Inhibition of DPP-4 (unknown origin) assessed as inhibition of endomorphin-2 degradation after 30 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50229666(Ile-Pro-Ile | (2S,3S)-2-((S)-1-((2S,3S)-2-amino-3-...)
Affinity DataKi:  2.20E+3nMAssay Description:Inhibition of DPP-4 (unknown origin) assessed as inhibition of endomorphin-1 degradation after 30 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50229666(Ile-Pro-Ile | (2S,3S)-2-((S)-1-((2S,3S)-2-amino-3-...)
Affinity DataKi:  3.90E+4nMAssay Description:Inhibition of human recombinant DPP8 assessed as Gly-Pro-pNA chromogenic substrate cleavage for 16 mins preincubated with compound for 10 mins before...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed