BDBM50295285 (4-Isobutyl-phenyl)-acetic acid::2-(4-isobutylphenyl)acetic acid::CHEMBL341812::Ibufenac

SMILES CC(C)Cc1ccc(CC(O)=O)cc1

InChI Key InChIKey=CYWFCPPBTWOZSF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50295285   

TargetInterleukin-8(Human)
Grupo Uriach

Curated by ChEMBL
LigandPNGBDBM50295285(Ibufenac | (4-Isobutyl-phenyl)-acetic acid | 2-(4-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50295285(Ibufenac | (4-Isobutyl-phenyl)-acetic acid | 2-(4-...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of mouse COX2-mediated 2-arachidonoylglycerol oxygenation preincubated for 3 mins before 2-arachidonoylglycerol addition measured after 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50295285(Ibufenac | (4-Isobutyl-phenyl)-acetic acid | 2-(4-...)
Affinity DataIC50: 4.17E+5nMAssay Description:Inhibition of rat ASIC3 receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.4-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetAcid-sensing ion channel 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50295285(Ibufenac | (4-Isobutyl-phenyl)-acetic acid | 2-(4-...)
Affinity DataIC50: 1.02E+6nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed