BDBM50556204 ITI 007::ITI-007::ITI-722::ITI007::Lumateperone::US12195462, Example 2

SMILES CN1CCN2c3c1cccc3[C@H]4[C@@H]2CCN(C4)CCCC(=O)c5ccc(cc5)F

InChI Key InChIKey=HOIIHACBCFLJET-UHFFFAOYSA-N

Data  6 KI  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50556204   

Target5-hydroxytryptamine receptor 2A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50556204(Lumateperone | ITI 007 | ITI-007 | ITI-722 | ITI00...)
Affinity DataIC50: 0.540nMAssay Description:Antagonist activity at 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50556204(Lumateperone | ITI 007 | ITI-007 | ITI-722 | ITI00...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of serotonin transporter (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50556204(Lumateperone | ITI 007 | ITI-007 | ITI-722 | ITI00...)
Affinity DataIC50: 4.10nMAssay Description:Partial agonist activity at presynaptic D2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50556204(Lumateperone | ITI 007 | ITI-007 | ITI-722 | ITI00...)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at postsynaptic D2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50556204(Lumateperone | ITI 007 | ITI-007 | ITI-722 | ITI00...)
Affinity DataKi:  0.540nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50556204(Lumateperone | ITI 007 | ITI-007 | ITI-722 | ITI00...)
Affinity DataKi:  10nMAssay Description:Receptor binding is determined for the Compounds of Examples 1, 2 and 3 (corresponding to Formula 1, Formula B and Formula A, respectively). The foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetSodium-dependent serotonin transporter(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50556204(Lumateperone | ITI 007 | ITI-007 | ITI-722 | ITI00...)
Affinity DataKi:  16nMAssay Description:Receptor binding is determined for the Compounds of Examples 1, 2 and 3 (corresponding to Formula 1, Formula B and Formula A, respectively). The foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetD(1A) dopamine receptor(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50556204(Lumateperone | ITI 007 | ITI-007 | ITI-722 | ITI00...)
Affinity DataKi:  41nMAssay Description:Receptor binding is determined for the Compounds of Examples 1, 2 and 3 (corresponding to Formula 1, Formula B and Formula A, respectively). The foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50556204(Lumateperone | ITI 007 | ITI-007 | ITI-722 | ITI00...)
Affinity DataKi:  49nMAssay Description:Receptor binding is determined for the Compounds of Examples 1, 2 and 3 (corresponding to Formula 1, Formula B and Formula A, respectively). The foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50556204(Lumateperone | ITI 007 | ITI-007 | ITI-722 | ITI00...)
Affinity DataKi: >1.00E+4nMAssay Description:Receptor binding is determined for the Compounds of Examples 1, 2 and 3 (corresponding to Formula 1, Formula B and Formula A, respectively). The foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent