BDBM20273 (2S)-2-[(2S)-2-[(4-cyanophenyl)formamido]-3-[4-(phosphonooxy)phenyl]propanamido]-4-methylpentanoic acid::ISS610

SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)c1ccc(cc1)C#N)C(O)=O

InChI Key InChIKey=HXSAWUQKNZJUNW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 20273   

LigandPNGBDBM20273((2S)-2-[(2S)-2-[(4-cyanophenyl)formamido]-3-[4-(ph...)
Affinity DataIC50: 4.20E+4nMpH: 7.8 T: 2°CAssay Description:STAT proteins were expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2008
Entry Details Article
PubMed
LigandPNGBDBM20273((2S)-2-[(2S)-2-[(4-cyanophenyl)formamido]-3-[4-(ph...)
Affinity DataIC50: 3.10E+5nMpH: 7.8 T: 2°CAssay Description:STAT proteins were expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2008
Entry Details Article
PubMed
LigandPNGBDBM20273((2S)-2-[(2S)-2-[(4-cyanophenyl)formamido]-3-[4-(ph...)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of STAT3 dimerization in v-Src transformed mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT3-DNA interaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM20273((2S)-2-[(2S)-2-[(4-cyanophenyl)formamido]-3-[4-(ph...)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of STAT3 (unknown origin) DNA binding activity by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed