BDBM50382559 ISPINESIB

SMILES Cc1ccc(cc1)C(=O)N(CCCN)[C@@H](C2=Nc3cc(ccc3C(=O)N2Cc4ccccc4)Cl)C(C)C

InChI Key InChIKey=QJZRFPJCWMNVAV-UHFFFAOYSA-N

Data  3 KI  9 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50382559   

TargetKinesin-like protein KIFC1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant N-terminal His6-tagged KIFC1 (Q305-K673 aa) (unknown origin) expressed in Escherichia coli BL21 (DE3) by malachite green as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2016
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
University of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataIC50: 47nMAssay Description:Inhibition of His-tagged KSP motor domain (1 to 369) (unknown origin) assessed as inhibition of microtubule-stimulated KSP ATPase activity preincuabt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKinesin-like protein KIF11(Human)
University of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataIC50: 5nMAssay Description:Inhibition of C-terminal His-tagged microtubule-stimulated KSP motor domain (1 to 369) ATPase activity (unknown origin) preincubated for 30 mins foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataIC50: 4.81E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataIC50: 2.43E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
University of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataKi:  2.30nMAssay Description:Inhibition of MT-stimulated human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain ATPase activity expressed in Escherichia col...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKinesin-like protein KIF11(Human)
University of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataKi:  2.30nMAssay Description:Inhibition of Kinesin Eg5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKinesin-like protein KIF11(Human)
University of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataKi:  2.5nMAssay Description:Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)