BDBM50222287 6,7-dihydroxy-4'-methoxyisoflavone::CHEMBL239028::IR-2::formonetin

SMILES COc1ccc(cc1)-c1coc2cc(O)c(O)cc2c1=O

InChI Key InChIKey=GCWOYVFHJDNKIN-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50222287   

TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
Universidad De Santiago

LigandPNGBDBM50222287(formonetin | 6,7-dihydroxy-4'-methoxyisoflavone | ...)
Affinity DataIC50: 1.00E+5nMpH: 7.3 T: 2°CAssay Description:The reactions were done in a volume of 2 mL and constantly stirred using a magnetic stir bar at room temperature (23 °C). Reactions with the crude, a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Universidad De Santiago

LigandPNGBDBM50222287(formonetin | 6,7-dihydroxy-4'-methoxyisoflavone | ...)
Affinity DataIC50: 1.20E+3nMpH: 7.3 T: 2°CAssay Description:The reactions were done in a volume of 2 mL and constantly stirred using a magnetic stir bar at room temperature (23 °C). Reactions with the crude, a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universidad De Santiago

LigandPNGBDBM50222287(formonetin | 6,7-dihydroxy-4'-methoxyisoflavone | ...)
Affinity DataIC50: 1.50E+5nMpH: 8.0Assay Description:Approximately 2 µg of either COX-1 or COX-2 was added to buffer containing 100 µM AA, 0.1 M Tris-HCl buffer (pH 8.0), 5 mM EDTA, 2 mM phenol, and 1 µ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Universidad De Santiago

LigandPNGBDBM50222287(formonetin | 6,7-dihydroxy-4'-methoxyisoflavone | ...)
Affinity DataIC50: 1.50E+5nMpH: 8.0Assay Description:Approximately 2 µg of either COX-1 or COX-2 was added to buffer containing 100 µM AA, 0.1 M Tris-HCl buffer (pH 8.0), 5 mM EDTA, 2 mM phenol, and 1 µ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
Universidad De Santiago

LigandPNGBDBM50222287(formonetin | 6,7-dihydroxy-4'-methoxyisoflavone | ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 15-hLO2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Universidad De Santiago De Chile

Curated by ChEMBL
LigandPNGBDBM50222287(formonetin | 6,7-dihydroxy-4'-methoxyisoflavone | ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 15-hLO1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
Universidad De Santiago De Chile

Curated by ChEMBL
LigandPNGBDBM50222287(formonetin | 6,7-dihydroxy-4'-methoxyisoflavone | ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 12-hLOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed