BDBM50146167 Capmatinib::INC-280::INCB-28060::NVP-INC280::US10738052, Example 7::US11261191, Example 7::US20240294535, Compound Capmatinib::US9944645, 7

SMILES CNC(=O)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1

InChI Key InChIKey=LIOLIMKSCNQPLV-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50146167   

TargetHepatocyte growth factor receptor(Human)
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50146167BDBM50146167(Capmatinib | INC-280 | INCB-28060 | NVP-INC280 | U...)
Affinity DataIC50: 0.00400nMAssay Description:Experimental methods: Enzyme reaction substrate, poly(Glu, Tyr)sodium salt (Glu:Tyr=4:1) was diluted with potassium-free phosphate buffered saline (P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

TargetHepatocyte growth factor receptor(Human)
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50146167BDBM50146167(Capmatinib | INC-280 | INCB-28060 | NVP-INC280 | U...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of human Nav1.2 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetHepatocyte growth factor receptor(Human)
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50146167BDBM50146167(Capmatinib | INC-280 | INCB-28060 | NVP-INC280 | U...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50146167BDBM50146167(Capmatinib | INC-280 | INCB-28060 | NVP-INC280 | U...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2017
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50146167BDBM50146167(Capmatinib | INC-280 | INCB-28060 | NVP-INC280 | U...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of MET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50146167BDBM50146167(Capmatinib | INC-280 | INCB-28060 | NVP-INC280 | U...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of c-MET (unknown origin) using TK substrate-biotin peptide as substrate preincubated for 5 to 10 mins followed by ATP addition measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50146167BDBM50146167(Capmatinib | INC-280 | INCB-28060 | NVP-INC280 | U...)
Affinity DataIC50: 0.700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetHepatocyte growth factor receptor(Human)
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50146167BDBM50146167(Capmatinib | INC-280 | INCB-28060 | NVP-INC280 | U...)
Affinity DataIC50: 500nMAssay Description:Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent

TargetHepatocyte growth factor receptor(Human)
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50146167BDBM50146167(Capmatinib | INC-280 | INCB-28060 | NVP-INC280 | U...)
Affinity DataIC50: 500nMAssay Description:Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
US Patent

TargetHepatocyte growth factor receptor(Human)
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50146167BDBM50146167(Capmatinib | INC-280 | INCB-28060 | NVP-INC280 | U...)
Affinity DataIC50: 500nMAssay Description:Briefly, histidine-tagged c-Met catalytic domain fusion protein was used for the assay. IC50 measurements were based on the degree of phosphorylation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetHepatocyte growth factor receptor(Human)
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50146167BDBM50146167(Capmatinib | INC-280 | INCB-28060 | NVP-INC280 | U...)
Affinity DataIC50: 3.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed