BDBM50252542 3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methyl)benzamide::CHEMBL492634::IN-1130

SMILES Cc1cccc(n1)-c1nc(Cc2cccc(c2)C(N)=O)[nH]c1-c1ccc2nccnc2c1

InChI Key InChIKey=RYKSGWSKILPDDY-UHFFFAOYSA-N

Data  22 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50252542   

TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 36nMAssay Description:Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human His-tagged TbetaR-1 assessed as inhibition of SMAD3 phosphorylation by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 13nMAssay Description:Inhibition of TGFBR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 17.2nMAssay Description:Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 cells using casein as a substrate by radioisotopic protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 17.2nMAssay Description:Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 cells using casein as a substrate by radioisotopic protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2013
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 480nMAssay Description:Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as a substrate by radioisotopic protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 480nMAssay Description:Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as a substrate by radioisotopic protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 480nMAssay Description:Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 480nMAssay Description:Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as a substrate by radioisotopic protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 480nMAssay Description:Inhibition of recombinant human p38-alpha expressed in Escherichia coli using ATF2 as substrate by radioisotope-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human recombinant p38alpha MAPK expressed in Escherichia coli by radioisotopic protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 36nMAssay Description:Inhibition of GST fused human recombinant ALK5 expressed in Sf9 cells by radioisotopic protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 480nMAssay Description:Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radioisotopic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant ALK5 expressed in insect Sf9 cells using casein as substrate by radioisotopic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetActivin receptor type-1B(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 23nMAssay Description:Inhibition of ALK4 (unknown origin) by radioisotopic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Mouse)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 44nMAssay Description:Inhibition of ALK5 in mouse 4T1 cells assessed as inhibition of TGFbeta1-induced luciferase activity after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 20nMAssay Description:Inhibition of ALK5 in human HaCaT cells assessed as inhibition of TGFbeta1-induced luciferase activity after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 2.44E+3nMAssay Description:Inhibition of VEGFR2 (unknown origin) by radioisotopic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 111nMAssay Description:Inhibition of RIPK2 (unknown origin) by radioisotopic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 17nMAssay Description:Inhibition of GST-fused recombinant human ALK5 expressed in baculovirus-infected insect Sf9 cells using casein as substrate by radioisotope-based ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed