BDBM50273160 IMARIKIREN

SMILES CC(C)CN([C@H]1C[C@H](CNC1)C(=O)N2CCOCC2)C(=O)c3nc4ccccc4n3CCCCOC

InChI Key InChIKey=RHIBAIKQWJNESW-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50273160   

TargetRenin(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273160(IMARIKIREN)
Affinity DataIC50: 0.430nMAssay Description:Inhibition of recombinant human renin using angiotensinogen as substrate pretreated for 10 mins followed by substrate addition measured after 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRenin(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273160(IMARIKIREN)
Affinity DataIC50: 0.840nMAssay Description:Inhibition of recombinant human renin using angiotensinogen as substrate pretreated for 10 mins followed by substrate addition measured after 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRenin(Rhesus macaque)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273160(IMARIKIREN)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of renin in monkey plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRenin(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273160(IMARIKIREN)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of renin in human plasma by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRenin(Rat)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50273160(IMARIKIREN)
Affinity DataIC50: 310nMAssay Description:Inhibition of renin in rat plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2020
Entry Details Article
PubMed