BDBM50136259 (2S,3S)-1-Methyl-piperidine-2,3-dicarboxylic acid 3-hydroxyamide 2-{[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-amide}::(2S,3S)-N3-hydroxy-1-methyl-N2-(4-((2-methylquinolin-4-yl)methoxy)phenyl)piperidine-2,3-dicarboxamide::CHEMBL134908::IM-491

SMILES CN1CCC[C@@H]([C@H]1C(=O)Nc1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO

InChI Key InChIKey=RJSKOAOWDAMMHR-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50136259   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136259((2S,3S)-N3-hydroxy-1-methyl-N2-(4-((2-methylquinol...)
Affinity DataIC50: 6.20nMAssay Description:In vitro binding affinity against porcine TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136259((2S,3S)-N3-hydroxy-1-methyl-N2-(4-((2-methylquinol...)
Affinity DataIC50: 6nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
The M. S. University of Baroda

Curated by ChEMBL
LigandPNGBDBM50136259((2S,3S)-N3-hydroxy-1-methyl-N2-(4-((2-methylquinol...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136259((2S,3S)-N3-hydroxy-1-methyl-N2-(4-((2-methylquinol...)
Affinity DataKi: >2.13E+3nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136259((2S,3S)-N3-hydroxy-1-methyl-N2-(4-((2-methylquinol...)
Affinity DataKi: >3.33E+3nMAssay Description:Inhibitory activity against matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136259((2S,3S)-N3-hydroxy-1-methyl-N2-(4-((2-methylquinol...)
Affinity DataKi: >4.95E+3nMAssay Description:Inhibitory activity against matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed