BDBM50020876 6-Butyl-4,10-dioxo-1,4,7,10-tetrahydro-[1,7]phenanthroline-2,8-dicarboxylic acid::6-Butyl-4,10-dioxo-1,4,7,10-tetrahydro-[1,7]phenanthroline-2,8-dicarboxylic acid(bufrolin)::CHEMBL150764::ICI-74917

SMILES CCCCc1cc2c(O)cc(nc2c2c(O)cc(nc12)C(O)=O)C(O)=O

InChI Key InChIKey=BQVIONBNDNFCCP-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50020876   

LigandPNGBDBM50020876(CHEMBL150764 | ICI-74917 | 6-Butyl-4,10-dioxo-1,4,...)
Affinity DataIC50: 2.22E+6nMAssay Description:50% inhibition of human placental alkaline phosphatase in the presence of 10 mM p-nitrophenyl phosphate as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
LigandPNGBDBM50020876(CHEMBL150764 | ICI-74917 | 6-Butyl-4,10-dioxo-1,4,...)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of cyclic GMP sensitive phosphodiesterase PDE 2 of human lungMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50020876(CHEMBL150764 | ICI-74917 | 6-Butyl-4,10-dioxo-1,4,...)
Affinity DataIC50: 9.70E+5nMAssay Description:Concentration required for 50% inhibition of human leukocyte alkaline phosphatase in the presence of 10 mM p-nitrophenyl phosphate as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
LigandPNGBDBM50020876(CHEMBL150764 | ICI-74917 | 6-Butyl-4,10-dioxo-1,4,...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of human lungMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50020876(CHEMBL150764 | ICI-74917 | 6-Butyl-4,10-dioxo-1,4,...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human GPR35 receptor expressed in HEK293T cells co-expressing beta-arrestin2 assessed as induction of beta-arrestin2 recruitment ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50020876(CHEMBL150764 | ICI-74917 | 6-Butyl-4,10-dioxo-1,4,...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human GPR35 by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed