BDBM50240404 (Ibudilast)1-(2-Isopropyl-pyrazolo[1,5-a]pyridin-3-yl)-2-methyl-propan-1-one::1-(2-isopropylH-pyrazolo[1,5-a]pyridin-3-yl)-2-methylpropan-1-one::CHEMBL19449::IBUDILAST

SMILES CC(C)c1c(c2ccccn2n1)C(=O)C(C)C

InChI Key InChIKey=ZJVFLBOZORBYFE-UHFFFAOYSA-N

Data  1 KI  12 IC50  1 Kd  1 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50240404   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50240404(CHEMBL19449 | (Ibudilast)1-(2-Isopropyl-pyrazolo[1...)
Affinity DataEC50:  900nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50240404(CHEMBL19449 | (Ibudilast)1-(2-Isopropyl-pyrazolo[1...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Heriot-Watt University

Curated by ChEMBL
LigandPNGBDBM50240404(CHEMBL19449 | (Ibudilast)1-(2-Isopropyl-pyrazolo[1...)
Affinity DataIC50: 1.03E+5nMAssay Description:Inhibition of human PDE5A catalytic domain using cAMP/cGMP substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Heriot-Watt University

Curated by ChEMBL
LigandPNGBDBM50240404(CHEMBL19449 | (Ibudilast)1-(2-Isopropyl-pyrazolo[1...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human PDE4B catalytic domain using cAMP/cGMP substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Heriot-Watt University

Curated by ChEMBL
LigandPNGBDBM50240404(CHEMBL19449 | (Ibudilast)1-(2-Isopropyl-pyrazolo[1...)
Affinity DataIC50: 2.99E+5nMAssay Description:Inhibition of human PDE3A catalytic domain using cAMP/cGMP substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50240404(CHEMBL19449 | (Ibudilast)1-(2-Isopropyl-pyrazolo[1...)
Affinity DataIC50: 54nMAssay Description:Inhibition of human PDE4AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Heriot-Watt University

Curated by ChEMBL
LigandPNGBDBM50240404(CHEMBL19449 | (Ibudilast)1-(2-Isopropyl-pyrazolo[1...)
Affinity DataIC50: 65nMAssay Description:Inhibition of human PDE4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50240404(CHEMBL19449 | (Ibudilast)1-(2-Isopropyl-pyrazolo[1...)
Affinity DataIC50: 239nMAssay Description:Inhibition of human PDE4CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50240404(CHEMBL19449 | (Ibudilast)1-(2-Isopropyl-pyrazolo[1...)
Affinity DataIC50: 166nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
L2 Diagnostics

Curated by ChEMBL
LigandPNGBDBM50240404(CHEMBL19449 | (Ibudilast)1-(2-Isopropyl-pyrazolo[1...)
Affinity DataKd:  1.40E+3nMAssay Description:Binding affinity to recombinant biotinylated human MIF expressed in Escherichia coli BL21 DE3 by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50240404(CHEMBL19449 | (Ibudilast)1-(2-Isopropyl-pyrazolo[1...)
Affinity DataIC50: 54nMAssay Description:Inhibition of human PDE4A expressed in insect sf9 cells using [3H]-cAMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Heriot-Watt University

Curated by ChEMBL
LigandPNGBDBM50240404(CHEMBL19449 | (Ibudilast)1-(2-Isopropyl-pyrazolo[1...)
Affinity DataIC50: 65nMAssay Description:Inhibition of human PDE4B expressed in insect sf9 cells using [3H]-cAMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50240404(CHEMBL19449 | (Ibudilast)1-(2-Isopropyl-pyrazolo[1...)
Affinity DataIC50: 239nMAssay Description:Inhibition of human PDE4C expressed in insect sf9 cells using [3H]-cAMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50240404(CHEMBL19449 | (Ibudilast)1-(2-Isopropyl-pyrazolo[1...)
Affinity DataIC50: 166nMAssay Description:Inhibition of human PDE4D expressed in insect sf9 cells using [3H]-cAMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
L2 Diagnostics

Curated by ChEMBL
LigandPNGBDBM50240404(CHEMBL19449 | (Ibudilast)1-(2-Isopropyl-pyrazolo[1...)
Affinity DataKi:  3.09E+4nMAssay Description:Non-competitive inhibition of recombinant human MIF assessed as inhibition constant using varying levels of p-hydroxyphenylpyruvate as substrate by L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)