BDBM8269 2-chloro-5-{[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino}benzoic acid::4-arylmaleimide deriv. 6-z::I-5

SMILES c1cc(cc(c1)Cl)C2=C(C(=O)NC2=O)Nc3ccc(c(c3)C(=O)O)Cl

InChI Key InChIKey=ONVZFCHLOZUXRP-UHFFFAOYSA-N

Data  6 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 8269   

TargetGlycogen synthase kinase-3 alpha(Human)
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM8269(2-chloro-5-{[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihy...)
Affinity DataIC50: 76nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM8269(2-chloro-5-{[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihy...)
Affinity DataIC50: 76nMAssay Description:Inhibition of human GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 beta(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM8269(2-chloro-5-{[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihy...)
Affinity DataIC50: 76nMAssay Description:Inhibition of recombinant GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 beta(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM8269(2-chloro-5-{[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihy...)
Affinity DataIC50: 160nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 alpha(Human)
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM8269(2-chloro-5-{[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihy...)
Affinity DataIC50: 76nMAssay Description:Inhibition of GSK3alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Rockefeller University

Curated by ChEMBL
LigandPNGBDBM8269(2-chloro-5-{[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2/cyclinA at 10 mMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM8269(2-chloro-5-{[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihy...)
Affinity DataKd:  40nMAssay Description:Binding affinity to GSK-3beta (unknown origin) expressed in Sf21 cells assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)