BDBM50468247 HM 781-36B::HM-781-36B::NOV-120101::Poziotinib::US11365189, Ex. No. 36::US11896597, Compound Poziotinib
SMILES COc1cc2ncnc(Nc3ccc(Cl)c(Cl)c3F)c2cc1OC1CCN(CC1)C(=O)C=C
InChI Key InChIKey=LPFWVDIFUFFKJU-UHFFFAOYSA-N
Data 28 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 28 hits for monomerid = 50468247
Affinity DataIC50: 5.20nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
Affinity DataIC50: 915nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 0.262nMAssay Description:Inhibition of EGFR A763-Y764 ins FQEA mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 197nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.151nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.137nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.0610nMAssay Description:Inhibition of EGFR D770-N771 ins NPG mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.270nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR (669 to 1210 residues) expressed in Sf21 insect cells using kinase substrate 22 incubated ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.40nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
Affinity DataIC50: 0.910nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Inhibition of GST-tagged human EGFR catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Dizal (Jiangsu) Pharmaceutical
US Patent
Dizal (Jiangsu) Pharmaceutical
US Patent
Affinity DataIC50: 0.800nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-769,'ASV',770-1210](Human)
Dizal (Jiangsu) Pharmaceutical
US Patent
Dizal (Jiangsu) Pharmaceutical
US Patent
Affinity DataIC50: 2nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-773,'NPH',774-1210](Human)
Dizal (Jiangsu) Pharmaceutical
US Patent
Dizal (Jiangsu) Pharmaceutical
US Patent
Affinity DataIC50: 2.10nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of C-terminal His6-tagged HER2 (703 to 1029 residues) (unknown origin) expressed in Sf9 insect cells using TK as substrate preincubated fo...More data for this Ligand-Target Pair
Affinity DataIC50: 0.218nMAssay Description:Inhibition of GST-tagged human EGFR D770_N771insNPG mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent k...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0780nMAssay Description:Inhibition of GST-tagged human EGFR A763_Y764insFHEA mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0780nMAssay Description:Inhibition of GST-tagged human EGFR A763_Y764insFHEA mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.218nMAssay Description:Inhibition of GST-tagged human EGFR D770_N771insNPG mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent k...More data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human EGFR T790M mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human EGFR T790M/L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.30nMAssay Description:Inhibition of GST-tagged human HER2 catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair