BDBM86728 1-(5-isoquinolinesulfonyl)-homopiperazine.HCl::CAS_105628-07-7::HA-1077

SMILES c1cc2cnccc2c(c1)S(=O)(=O)N3CCCNCC3

InChI Key InChIKey=NGOGFTYYXHNFQH-UHFFFAOYSA-N

Data  3 IC50

PDB links: 15 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 86728   

TargetRho-associated protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 86728BDBM86728(1-(5-isoquinolinesulfonyl)-homopiperazine.HCl | CA...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of His6-tagged ROCK2 (2 to 543 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of ATP by immunoblo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 86728BDBM86728(1-(5-isoquinolinesulfonyl)-homopiperazine.HCl | CA...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of GST-tagged LRRK2 G2019S mutant (1326 to 2527 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 86728BDBM86728(1-(5-isoquinolinesulfonyl)-homopiperazine.HCl | CA...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of GST-tagged LRRK2 (1326 to 2527 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of ATP by immuno...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed