BDBM11458 2,6,9-trisubstituted adenine derivative::2-N-(4-aminocyclohexyl)-9-cyclopentyl-6-N-[(3-iodophenyl)methyl]-9H-purine-2,6-diamine::H327

SMILES N[C@H]1CC[C@@H](CC1)Nc1nc(NCc2cccc(I)c2)c2ncn(C3CCCC3)c2n1

InChI Key InChIKey=SCAGLYMBBLMFND-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 11458   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Lawrence Berkeley National Laboratory

LigandPNGBDBM11458(2,6,9-trisubstituted adenine derivative | 2-N-(4-a...)
Affinity DataIC50: 50nMpH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 10 uM ATP/[gamma-33P] ATP, and capturing the 33-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Lawrence Berkeley National Laboratory

LigandPNGBDBM11458(2,6,9-trisubstituted adenine derivative | 2-N-(4-a...)
Affinity DataIC50: 2.00E+3nMpH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 10 uM ATP/[gamma-33P] ATP, and capturing the 33-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Lawrence Berkeley National Laboratory

LigandPNGBDBM11458(2,6,9-trisubstituted adenine derivative | 2-N-(4-a...)
Affinity DataIC50: 226nMpH: 8.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 0.5 uM ATP/ [gamma-33P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed