BDBM50358043 CHEMBL1794051::GW-5074

SMILES OC1Nc2ccc(I)cc2C1=Cc1cc(Br)c(O)c(Br)c1

InChI Key InChIKey=UFKSWYKDQZBJTH-UHFFFAOYSA-N

Data  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50358043   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 170nMAssay Description:Inhibition of c-Raf in the presence of 100uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 2.87nMAssay Description:inhibition of RAF1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 2.87nMAssay Description:Inhibition of C-Raf assessed as [33P]gamma-ATP incorporation into substrate after 40 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Ludwig-Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 4.16E+4nMAssay Description:Inhibition of human recombinant N-terminally GST-tagged SIRT1 after 4 hrs in presence of NAD+ by fluorescent deacetylase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
Ludwig-Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of human recombinant N-terminally 6X-His-tagged SIRT3 after 4 hrs in presence of NAD+ by fluorescent deacetylase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Ludwig-Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 1.56E+4nMAssay Description:Inhibition of human recombinant N-terminally 6X-His-tagged SIRT2 after 4 hrs in presence of NAD+ by fluorescent deacetylase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 9nMAssay Description:Inhibition of Raf1 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-3(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 100nMAssay Description:Inhibition of PIM3 in the presence of 20uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 70nMAssay Description:Inhibition of PIM2 in the presence of 5uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 170nMAssay Description:Inhibition of PIM1 in the presence of 20uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human CRAF using [gamma-33P]ATP after 40 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 190nMAssay Description:Inhibition of B-Raf in the presence of 100uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 1.95E+4nMAssay Description:Inhibition of human Sirt5 desuccinylation activity using SKEYFS-succinylLys-QK as substrate measured for 15 mins by MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 9.78E+4nMAssay Description:Inhibition of human Sirt5 deacetylation activity using FKRGVL-acetylLys-EYGVKV as substrate measured for 15 mins by MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human Sirt5 deacetylation activity using SKEYFS-acetylLys-QK as substrate measured for 15 mins by MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 11nMAssay Description:Inhibition of c-Raf1 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of receptor Tyrosine kinase A, TrkA (nerve growth factor receptor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 9nMAssay Description:Inhibitory concentration against raf kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 9nMAssay Description:Inhibition of cRaf1 kinase in cascade assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed