BDBM50652774 GSK-295::GSK-923295::GSK-923295A::GSK923295::Gsk-923295a::Gsk923295

SMILES CC(C)Oc1ccc(C(=O)N[C@H](CNC(=O)CN(C)C)Cc2ccc(-c3cn4cccc([C@H](C)O)c4n3)cc2)cc1Cl

InChI Key InChIKey=WHMXDBPHBVLYRC-UHFFFAOYSA-N

Data  11 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50652774   

TargetCentromere-associated protein E(Human)
Children's Hospital of Philadelphia

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataIC50: 134nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Children's Hospital of Philadelphia

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataIC50: 17nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Children's Hospital of Philadelphia

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataIC50: 56nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Children's Hospital of Philadelphia

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataIC50: 42nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Children's Hospital of Philadelphia

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataIC50: 52nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Children's Hospital of Philadelphia

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataIC50: 283nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Children's Hospital of Philadelphia

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataIC50: 2.08E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Children's Hospital of Philadelphia

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataIC50: 2.30nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCentromere protein E(Canis lupus familiaris)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataKi:  1.60nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Children's Hospital of Philadelphia

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataKi:  3.10nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Children's Hospital of Philadelphia

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataKi:  3.20nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Children's Hospital of Philadelphia

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataKi:  3.20nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Children's Hospital of Philadelphia

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Children's Hospital of Philadelphia

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataKi:  13nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Children's Hospital of Philadelphia

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataKi:  14nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Children's Hospital of Philadelphia

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataKi:  18nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Children's Hospital of Philadelphia

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataKi:  61nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Children's Hospital of Philadelphia

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataKi:  64nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCentromere-associated protein E(Mus musculus)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataKi:  67nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed