BDBM50559516 GSK-189075::GSK-189075A::GSK189075A::Remogliflozin etabonate

SMILES [H][C@]1(COC(=O)OCC)O[C@@]([H])(Oc2nn(C(C)C)c(C)c2Cc2ccc(OC(C)C)cc2)[C@]([H])(O)[C@@]([H])(O)[C@]1([H])O

InChI Key InChIKey=UAOCLDQAQNNEAX-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50559516   

TargetSodium/glucose cotransporter 2(Human)
Toho University

Curated by ChEMBL
LigandPNGBDBM50559516(Remogliflozin etabonate | GSK-189075 | GSK-189075A...)
Affinity DataIC50: 2.53E+3nMAssay Description:Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Toho University

Curated by ChEMBL
LigandPNGBDBM50559516(Remogliflozin etabonate | GSK-189075 | GSK-189075A...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human SGLT1 expressed in COS7 cells assessed as reduction in [14C]-AMG uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Toho University

Curated by ChEMBL
LigandPNGBDBM50559516(Remogliflozin etabonate | GSK-189075 | GSK-189075A...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human SGLT1 expressed in COS-7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetSodium/glucose cotransporter 2(Human)
Toho University

Curated by ChEMBL
LigandPNGBDBM50559516(Remogliflozin etabonate | GSK-189075 | GSK-189075A...)
Affinity DataIC50: 2.53E+3nMAssay Description:Inhibition of human SGLT2 expressed in COS-7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetSodium/glucose cotransporter 2(Human)
Toho University

Curated by ChEMBL
LigandPNGBDBM50559516(Remogliflozin etabonate | GSK-189075 | GSK-189075A...)
Affinity DataKi:  12nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium/glucose cotransporter 1(Human)
Toho University

Curated by ChEMBL
LigandPNGBDBM50559516(Remogliflozin etabonate | GSK-189075 | GSK-189075A...)
Affinity DataKi:  4.52E+3nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed