BDBM36350 6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-quinolinone::CID12000936::GSK-1

SMILES FC(F)(F)c1ccc(cc1)-c1ccc2NC(=O)CCc2c1

InChI Key InChIKey=WNVWLPPJRMIRBG-UHFFFAOYSA-N

Data  3 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 36350   

TargetKinesin-like protein KIF11(Human)
Glaxosmithkline

LigandPNGBDBM36350(CID12000936 | 6-[4-(Trifluoromethyl)phenyl]-3,4-di...)
Affinity DataIC50: 36nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Glaxosmithkline

LigandPNGBDBM36350(CID12000936 | 6-[4-(Trifluoromethyl)phenyl]-3,4-di...)
Affinity DataIC50: 36nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Glaxosmithkline

LigandPNGBDBM36350(CID12000936 | 6-[4-(Trifluoromethyl)phenyl]-3,4-di...)
Affinity DataIC50: 162nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Glaxosmithkline

LigandPNGBDBM36350(CID12000936 | 6-[4-(Trifluoromethyl)phenyl]-3,4-di...)
Affinity DataIC50: 2.09E+3nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetKinesin-like protein KIF11 [D130V](Human)
Glaxosmithkline

LigandPNGBDBM36350(CID12000936 | 6-[4-(Trifluoromethyl)phenyl]-3,4-di...)
Affinity DataIC50: 0.450nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetKinesin-like protein KIF11 [D130V](Human)
Glaxosmithkline

LigandPNGBDBM36350(CID12000936 | 6-[4-(Trifluoromethyl)phenyl]-3,4-di...)
Affinity DataIC50: 0.830nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetKinesin-like protein KIF11 [D130V](Human)
Glaxosmithkline

LigandPNGBDBM36350(CID12000936 | 6-[4-(Trifluoromethyl)phenyl]-3,4-di...)
Affinity DataIC50: 3.30nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetKinesin-like protein KIF11 [D130V](Human)
Glaxosmithkline

LigandPNGBDBM36350(CID12000936 | 6-[4-(Trifluoromethyl)phenyl]-3,4-di...)
Affinity DataIC50: 6.90nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Glaxosmithkline

LigandPNGBDBM36350(CID12000936 | 6-[4-(Trifluoromethyl)phenyl]-3,4-di...)
Affinity DataIC50: 46nMAssay Description:Inhibition of C-terminally His6-tagged microtubule-activated KSP motor domain ATPase activity after 15 mins by luciferase-derived luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Glaxosmithkline

LigandPNGBDBM36350(CID12000936 | 6-[4-(Trifluoromethyl)phenyl]-3,4-di...)
Affinity DataKi:  1.70nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetKinesin-like protein KIF11 [A356T](Human)
Glaxosmithkline

LigandPNGBDBM36350(CID12000936 | 6-[4-(Trifluoromethyl)phenyl]-3,4-di...)
Affinity DataKi:  66nMpH: 6.8Assay Description:wild-type HCT116 selected at 6WT-6x the IC95More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetKinesin-like protein KIF11 [A356T](Human)
Glaxosmithkline

LigandPNGBDBM36350(CID12000936 | 6-[4-(Trifluoromethyl)phenyl]-3,4-di...)
Affinity DataKi:  109nMpH: 6.8Assay Description:wild-type HCT116 selected at 3 the IC95More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed