BDBM27217 (2R)-2-{[4-(benzylamino)-8-(propan-2-yl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol::GP0210::pyrazolo[1,5-a]-1,3,5-triazine, 7a

SMILES CC[C@H](CO)Nc1nc(NCc2ccccc2)n2ncc(C(C)C)c2n1

InChI Key InChIKey=SQUNOCMDMIQIQK-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 27217   

LigandPNGBDBM27217(GP0210 | (2R)-2-{[4-(benzylamino)-8-(propan-2-yl)p...)
Affinity DataIC50: 73nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2009
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Universite De Lyon

LigandPNGBDBM27217(GP0210 | (2R)-2-{[4-(benzylamino)-8-(propan-2-yl)p...)
Affinity DataIC50: 40nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Human)
Universite De Lyon

LigandPNGBDBM27217(GP0210 | (2R)-2-{[4-(benzylamino)-8-(propan-2-yl)p...)
Affinity DataIC50: 70nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2009
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Universite De Lyon

LigandPNGBDBM27217(GP0210 | (2R)-2-{[4-(benzylamino)-8-(propan-2-yl)p...)
Affinity DataIC50: 500nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2009
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Universite De Lyon

LigandPNGBDBM27217(GP0210 | (2R)-2-{[4-(benzylamino)-8-(propan-2-yl)p...)
Affinity DataIC50: 43nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2009
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM27217(GP0210 | (2R)-2-{[4-(benzylamino)-8-(propan-2-yl)p...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli in presence of [gamma-33P]ATP after 30 mins by scintillation counting an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM27217(GP0210 | (2R)-2-{[4-(benzylamino)-8-(propan-2-yl)p...)
Affinity DataIC50: 43nMAssay Description:Inhibition of human recombinant CDK5/p25 using histone H1 and [gamma-33P]ATP incubated fro 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Universite De Lyon

LigandPNGBDBM27217(GP0210 | (2R)-2-{[4-(benzylamino)-8-(propan-2-yl)p...)
Affinity DataIC50: 43nMAssay Description:Inhibition of human recombinant CDK2/cyclin A using histone H1 and [gamma-33P]ATP incubated fro 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Universite De Lyon

LigandPNGBDBM27217(GP0210 | (2R)-2-{[4-(benzylamino)-8-(propan-2-yl)p...)
Affinity DataIC50: 43nMAssay Description:Inhibition of human recombinant CDK7/cyclin H using histone H1 and [gamma-33P]ATP incubated fro 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Universite De Lyon

LigandPNGBDBM27217(GP0210 | (2R)-2-{[4-(benzylamino)-8-(propan-2-yl)p...)
Affinity DataIC50: 43nMAssay Description:Inhibition of human recombinant CDK9/cyclin T expressed in insect cells using pRb fragment (773 to 928 amino acids) and [gamma-33P]ATP incubated fro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM27217(GP0210 | (2R)-2-{[4-(benzylamino)-8-(propan-2-yl)p...)
Affinity DataIC50: 43nMAssay Description:Inhibition of human recombinant CDK2/cyclinE using histone H1 and [gamma-33P]ATP incubated fro 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Universite De Lyon

LigandPNGBDBM27217(GP0210 | (2R)-2-{[4-(benzylamino)-8-(propan-2-yl)p...)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human CDK2/cyclin A after 30 mins in presence of [gamma-33P]ATP by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM27217(GP0210 | (2R)-2-{[4-(benzylamino)-8-(propan-2-yl)p...)
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant human CDK2/cyclin E after 30 mins in presence of [gamma-33P]ATP by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM27217(GP0210 | (2R)-2-{[4-(benzylamino)-8-(propan-2-yl)p...)
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human CDK5/p25 after 30 mins in presence of [gamma-33P]ATP by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Universite De Lyon

LigandPNGBDBM27217(GP0210 | (2R)-2-{[4-(benzylamino)-8-(propan-2-yl)p...)
Affinity DataIC50: 43nMAssay Description:Inhibition of recombinant human CDK9/cyclin T after 30 mins in presence of [gamma-33P]ATP by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed