BDBM50187063 CHEMBL379386::GNF-PF-2722::N2-(4-bromophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine

SMILES Brc1ccc(Nc2nc(NCc3ccco3)c3ccccc3n2)cc1

InChI Key InChIKey=WYDGHRZFSRBHSA-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50187063   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Mouse)
Research Center Idrtech

Curated by ChEMBL
LigandPNGBDBM50187063(N2-(4-bromophenyl)-N4-(furan-2-ylmethyl)quinazolin...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of mouse Dyrk1A autophosphorylation in HEk293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50187063(N2-(4-bromophenyl)-N4-(furan-2-ylmethyl)quinazolin...)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed