BDBM50428123 CHEMBL2331680::GDC-0349

SMILES CCNC(=O)Nc1ccc(cc1)-c1nc2CN(CCc2c(n1)N1CCOC[C@@H]1C)C1COC1

InChI Key InChIKey=RGJOJUGRHPQXGF-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50428123   

TargetCytochrome P450 3A4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50428123(GDC-0349 | CHEMBL2331680)
Affinity DataIC50: 1.00E+4nMAssay Description:Time-dependent inhibition of CYP3A4 in human liver microsome using midazolam as substrate by TDI shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50428123(GDC-0349 | CHEMBL2331680)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50428123(GDC-0349 | CHEMBL2331680)
Affinity DataIC50: 39nMAssay Description:Inhibition of mTOR (unknown origin) by Kinase-Glo plus luminescence kinase assay or and ADP-Glo Plus luminescence kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50428123(GDC-0349 | CHEMBL2331680)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using lipid substrate by Kinase-Glo plus luminescence kinase assay or and ADP-Glo Plus luminescence kinase a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50428123(GDC-0349 | CHEMBL2331680)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50428123(GDC-0349 | CHEMBL2331680)
Affinity DataKi:  3.80nMAssay Description:Inhibition of recombinant mTOR (1360 to 2549)+GBL (unknown origin) using GFP-4E-BP1 as substrate after 30 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed