BDBM50561689 Dotinurad::Fyu-981

SMILES c1ccc2c(c1)N(CS2(=O)=O)C(=O)c3cc(c(c(c3)Cl)O)Cl

InChI Key InChIKey=VOFLAIHEELWYGO-UHFFFAOYSA-N

Data  4 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50561689   

TargetCytochrome P450 2C9(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561689(Dotinurad | Fyu-981)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561689(Dotinurad | Fyu-981)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561689(Dotinurad | Fyu-981)
Affinity DataIC50: 37nMAssay Description:Inhibition of human URAT1 expressed in Xenopus laevis oocytes assessed as inhibition of [14C]uric acid uptake measured after 60 mins by liquid scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50561689(Dotinurad | Fyu-981)
Affinity DataIC50: 37nMAssay Description:Inhibition of ABCG2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed