BDBM50546200 BIIB-062::BSK-4841::FP-0182::FP0182::Sns-062::Vecabrutinib

SMILES NC(=O)[C@H]1CCN(C[C@@H]1N1CCC[C@@H](Nc2cc(Cl)cc(c2)C(F)(F)F)C1=O)c1ncnc(N)c1F

InChI Key InChIKey=QLRRJMOBVVGXEJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50546200   

TargetTyrosine-protein kinase BTK(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546200(Vecabrutinib | Sns-062 | BIIB-062 | BSK-4841 | FP-...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of BTK C481S (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546200(Vecabrutinib | Sns-062 | BIIB-062 | BSK-4841 | FP-...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of wild type BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546200(Vecabrutinib | Sns-062 | BIIB-062 | BSK-4841 | FP-...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of recombinant human BTK measured by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546200(Vecabrutinib | Sns-062 | BIIB-062 | BSK-4841 | FP-...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human BTK C481S mutant measured by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546200(Vecabrutinib | Sns-062 | BIIB-062 | BSK-4841 | FP-...)
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546200(Vecabrutinib | Sns-062 | BIIB-062 | BSK-4841 | FP-...)
Affinity DataIC50: 17nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed