BDBM50024458 5-oxo-ETE::CHEMBL18028::ETE-5-Oxo

SMILES CCCCC\C=C/C\C=C/CC=CC=CC(=O)CCCC(O)=O

InChI Key InChIKey=MEASLHGILYBXFO-UHFFFAOYSA-N

Data  2 KI  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50024458   

TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
University of California

Curated by ChEMBL
LigandPNGBDBM50024458(ETE-5-Oxo | CHEMBL18028 | 5-oxo-ETE)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of rabbit reticulocyte 15-LOX by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50024458(ETE-5-Oxo | CHEMBL18028 | 5-oxo-ETE)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human reticulocyte 15-lipoxygenase-2 by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50024458(ETE-5-Oxo | CHEMBL18028 | 5-oxo-ETE)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human reticulocyte 15-lipoxygenase-1 by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50024458(ETE-5-Oxo | CHEMBL18028 | 5-oxo-ETE)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human platelet 12-lipoxygenase by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetOxoeicosanoid receptor 1(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50024458(ETE-5-Oxo | CHEMBL18028 | 5-oxo-ETE)
Affinity DataIC50: 3nMAssay Description:Desensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetOxoeicosanoid receptor 1(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50024458(ETE-5-Oxo | CHEMBL18028 | 5-oxo-ETE)
Affinity DataEC50:  7nMAssay Description:Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandPNGBDBM50024458(ETE-5-Oxo | CHEMBL18028 | 5-oxo-ETE)
Affinity DataIC50: 1.80E+4nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase from rat basophilic leukemia cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetOxoeicosanoid receptor 1(Human)
Florida Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50024458(ETE-5-Oxo | CHEMBL18028 | 5-oxo-ETE)
Affinity DataEC50:  220nMAssay Description:Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2020
Entry Details Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
Schering-Plough Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50024458(ETE-5-Oxo | CHEMBL18028 | 5-oxo-ETE)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details Article
PubMed
TargetLeukotriene B4 receptor 2(Human)
Schering-Plough Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50024458(ETE-5-Oxo | CHEMBL18028 | 5-oxo-ETE)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details Article
PubMed