BDBM50366524 ESTRONE::ESTROPIPATE::Estrone 3-sulfate::Estrone Sulphate

SMILES C[C@]12CC[C@H]3[C@@H](CCc4cc(OS(O)(=O)=O)ccc34)[C@@H]1CCC2=O

InChI Key InChIKey=JKKFKPJIXZFSSB-UHFFFAOYSA-N

Data  9 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50366524   

TargetSteryl-sulfatase(Human)
Laval University

Curated by ChEMBL
LigandPNGBDBM50366524(Estrone Sulphate | ESTRONE | ESTROPIPATE | Estrone...)
Affinity DataIC50: 7.60E+3nMAssay Description:Estrone-sulfatase activity against homogenized human JEG-3 cells was determined by measuring the [3H]E1 obtained from [3H]E1SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
Laval University

Curated by ChEMBL
LigandPNGBDBM50366524(Estrone Sulphate | ESTRONE | ESTROPIPATE | Estrone...)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of steroid sulfatase activity of JEG-3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 4(Human)
The Netherlands Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50366524(Estrone Sulphate | ESTRONE | ESTROPIPATE | Estrone...)
Affinity DataIC50: 4.50E+4nMAssay Description:TP_TRANSPORTER: inhibition of E217betaG uptake in membrane vesicles from MRP4-expressing Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 4(Human)
The Netherlands Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50366524(Estrone Sulphate | ESTRONE | ESTROPIPATE | Estrone...)
Affinity DataIC50: 9.50E+4nMAssay Description:TP_TRANSPORTER: inhibition of DHEAS in membrane vesicles from MRP4-expressing Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier organic anion transporter family member 1B1(Human)
Kanazawa University

Curated by ChEMBL
LigandPNGBDBM50366524(Estrone Sulphate | ESTRONE | ESTROPIPATE | Estrone...)
Affinity DataKi:  46nMAssay Description:TP_TRANSPORTER: inhibition of E217betaG uptake in OATP-C-expressing HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50366524(Estrone Sulphate | ESTRONE | ESTROPIPATE | Estrone...)
Affinity DataKi:  450nMAssay Description:TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicle from MRP1-expressing HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetSolute carrier organic anion transporter family member(Zebrafish)
Rudjer Boskovic Institute

LigandPNGBDBM50366524(Estrone Sulphate | ESTRONE | ESTROPIPATE | Estrone...)
Affinity DataKi:  1.01E+3nMAssay Description:In the inhibition experiments, the cells were preincubated for 20 s with test compounds, followed by a 5-min incubation with [3H]E3S (5 nM) or 30-min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2017
Entry Details Article
PubMed
TargetSolute carrier organic anion transporter family member 1A1(Rat)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50366524(Estrone Sulphate | ESTRONE | ESTROPIPATE | Estrone...)
Affinity DataKi:  1.30E+3nMAssay Description:TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp1-expressing HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Rat)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50366524(Estrone Sulphate | ESTRONE | ESTROPIPATE | Estrone...)
Affinity DataKi:  9.10E+3nMAssay Description:TP_TRANSPORTER: inhibition of PCG uptake in OAT3-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetSolute carrier organic anion transporter family member 1C1(Mouse)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50366524(Estrone Sulphate | ESTRONE | ESTROPIPATE | Estrone...)
Affinity DataKi:  5.31E+4nMAssay Description:TP_TRANSPORTER: inhibition of L-T4 uptake in Oatp14-expressing HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetSolute carrier family 22 member 20(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50366524(Estrone Sulphate | ESTRONE | ESTROPIPATE | Estrone...)
Affinity DataKi:  5.80E+4nMAssay Description:Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
Laval University

Curated by ChEMBL
LigandPNGBDBM50366524(Estrone Sulphate | ESTRONE | ESTROPIPATE | Estrone...)
Affinity DataKi:  6.00E+4nMAssay Description:Competitive inhibitory activity against steroid sulfatase (STS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50366524(Estrone Sulphate | ESTRONE | ESTROPIPATE | Estrone...)
Affinity DataKi:  2.03E+5nMAssay Description:Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed