BDBM50085047 2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl ester::2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester::CHEMBL565::Clofibrate::EPIB::ETHYL CLOFIBRATE::Ethyl 2-(p-chlorophenoxy)isobutyrate::Ethyl chlorophenoxyisobutyrate::Liprin::alpha-(p-Chlorophenoxy)isobutyric acid, ethyl ester::alpha-p-Chlorophenoxyisobutyryl ethyl ester::ethyl 2-(4-chlorophenoxy)-2-methylpropanoate

SMILES CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1

InChI Key InChIKey=KNHUKKLJHYUCFP-UHFFFAOYSA-N

Data  2 KI  8 IC50  8 Kd  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50085047   

TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataKd:  7.80E+3nMAssay Description:Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 20 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataEC50:  5.50E+7nMAssay Description:Agonist activity at mouse PPARalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataIC50: 7.10E+4nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2019
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
University of Lille Nord de France

Curated by ChEMBL
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataEC50:  5.50E+4nMAssay Description:Agonist activity at PPARalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataKd:  1.20E+4nMAssay Description:Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 42 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataKd:  1.10E+4nMAssay Description:Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 37 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataKd:  9.60E+3nMAssay Description:Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 30 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataKd:  8.90E+3nMAssay Description:Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 25 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataKd:  7.30E+3nMAssay Description:Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 15 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataKd:  6.70E+3nMAssay Description:Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 10 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataKd:  6.00E+3nMAssay Description:Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 5 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
University of Lille Nord de France

Curated by ChEMBL
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataEC50:  5.50E+4nMAssay Description:Effective concentration against human peroxisome proliferator activated receptor alpha in Gal4 transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Glaxo Wellcome Research & Development

Curated by ChEMBL
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataEC50:  5.00E+5nMAssay Description:Agonist activity for Human PPAR gamma receptor in transcriptional activation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataEC50:  5.00E+4nMAssay Description:Agonist activity for murine PPAR alpha receptor in transcriptional activation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Mouse)
Glaxo Wellcome Research & Development

Curated by ChEMBL
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataEC50:  5.00E+5nMAssay Description:Agonist activity for murine PPAR gamma receptor in transcriptional activation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
University of Lille Nord de France

Curated by ChEMBL
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataEC50:  5.50E+4nMAssay Description:Agonist activity for Human PPAR alpha receptor in transcriptional activation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataIC50: 8.60E+5nMAssay Description:Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of nonsaponifiable lipid synthesis using [2-14C]ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataIC50: 6.30E+5nMAssay Description:Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of total lipid synthesis using [2-14C]acetate as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataIC50: 4.40E+5nMAssay Description:Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of fatty acid synthesis using [2-14C]acetate as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetFatty acid-binding protein, liver(Rat)
Monash University

Curated by ChEMBL
LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataKi:  6.92E+3nMAssay Description:Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSolute carrier organic anion transporter family member(Zebrafish)
Rudjer Boskovic Institute

LigandPNGBDBM50085047(ethyl 2-(4-chlorophenoxy)-2-methylpropanoate | 2-(...)
Affinity DataKi:  3.45E+5nMAssay Description:In the inhibition experiments, the cells were preincubated for 20 s with test compounds, followed by a 5-min incubation with [3H]E3S (5 nM) or 30-min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2017
Entry Details Article
PubMed