BDBM50001465 (S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid::([Leu]-enkephalin)2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid::(enkephalin)2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid::2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-1-oxo-3-phenyl-propylamino]-4-methyl-pentanoic acid::2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid::2-[1-[1-amino-2-(4-hydroxyphenyl)-(1S)-ethylcarboxamidomethylcarboxamidomethylcarboxamido]-2-phenyl-(1S)-ethylcarboxamido]-4-methyl-(2S)-pentanoic acid::2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid::2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid(Enkephalin)::2-{1-[1-amino-2-(4-hydroxyphenyl)ethylcarboxamidomethylcarboxamidomethylcarboxamido]-2-phenylethylcarboxamido}-4-methylpentanoic acid::CHEMBL8234::ENKEPHALIN::Leu-ENKEPHALIN::Leu5-Enkephalin::Tyr-Gly-Gly-Phe-Leu-OH
SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(O)=O
InChI Key InChIKey=URLZCHNOLZSCCA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 102 hits for monomerid = 50001465
Affinity DataKd: 7.10nMAssay Description:Dissociation constant when the monoclonal antibody 3-E7 bound tightly to [Leu]enkephalinMore data for this Ligand-Target Pair
Affinity DataIC50: 103nMAssay Description:In vitro inhibitory activity was determined against Opioid receptor mu 1 in guinea pig ileumMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibitory activity against Opioid receptor delta 1 of (endomorphin 2) in mouse vas deferens was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 246nMAssay Description:Inhibitory potency against Opioid receptor mu 1 in the guinea pig ileum assayMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of [3H]-naloxone binding to mu receptor in rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataIC50: 9.40nMAssay Description:Ability to induce 50% of maximal effect in mouse vas deferens expressing Opioid receptor delta 1More data for this Ligand-Target Pair
Affinity DataIC50: 246nMAssay Description:Inhibition of electrically evoked contractions in Guinea pig ileumMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of electrically evoked contractions in mouse vas deferensMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibitory potency against Opioid receptor delta 1 in the mouse vas deferens assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of binding of [3H][D-Ala2,D-Leu5]enkephalin to Opioid receptor delta 1 in the rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibitory activity against non-selective opiate receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 246nMAssay Description:Antagonist activity at MOR in guinea pig ileum assessed as inhibition of electrically-stimulated muscle contractionMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1(Mouse)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 8.40nMAssay Description:Concentration required to inhibit the specific binding of tritiated ligand [3H]DADL to opiate receptor by 50%More data for this Ligand-Target Pair
TargetDelta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1(Mouse)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:Concentration required to inhibit the specific binding of tritiated ligand [3H]-naloxone to opiate receptor by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]naloxone from Sprague-Dawley rat cerebellum opioid receptor assessed as relative receptor affinity by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Agonist activity at delta opioid receptor in mouse vas deferensMore data for this Ligand-Target Pair
Affinity DataIC50: 246nMAssay Description:Agonist activity at mu opioid receptor in guinea pig ileumMore data for this Ligand-Target Pair
Affinity DataEC50: 80nMAssay Description:Activation of kappa opioid receptor (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1.30nMAssay Description:Agonist activity at mu opioid receptor (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 80nMAssay Description:Agonist activity at kappa opioid receptor (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0800nMAssay Description:Agonist activity at delta opioid receptor (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 74nMAssay Description:Agonist activity at delta opioid receptor in mouse vas deferens assessed as inhibition of electric-field induced measured after 5 minsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0800nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for...More data for this Ligand-Target Pair
Affinity DataEC50: 1.30nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30...More data for this Ligand-Target Pair
Affinity DataEC50: 80nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for...More data for this Ligand-Target Pair
Affinity DataEC50: 178nMAssay Description:Agonist activity at MOP (unknown origin) expressed in SH-SY5Y cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein act...More data for this Ligand-Target Pair
Affinity DataEC50: 794nMAssay Description:Agonist activity at MOP (unknown origin) expressed in SH-SY5Y cell membranes co-expressing beta-arrestin2-RGFP protein assessed as induction of beta-...More data for this Ligand-Target Pair
Affinity DataEC50: 120nMAssay Description:Agonist activity at DOP (unknown origin) expressed in SH-SY5Y cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein act...More data for this Ligand-Target Pair
Affinity DataEC50: 43nMAssay Description:Agonist activity at DOP (unknown origin) expressed in SH-SY5Y cell membranes co-expressing beta-arrestin2-RGFP protein assessed as induction of beta-...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Agonist activity at mouse FLAG-tagged delta opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP production pre...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Agonist activity at mouse FLAG-tagged delta opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP production pre...More data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO-K1 cells assessed as beta-arrestin2 recruitment incubated for 90 mins by PathHunter ...More data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Agonist activity at human DOR expressed in CHO cells assessed as reduction in ERK1/2 phosphorylation levelMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Agonist activity at FLAG-tagged mouse delta opioid receptor expressed in human HEK293 cells assessed as inhibition of forskolin stimulated cAMP produ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Agonist activity at FLAG-tagged mouse delta opioid receptor expressed in human HEK293 cells assessed as inhibition of forskolin stimulated cAMP produ...More data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO cells co-expressing beta-arrestin2 assessed as beta-arrestin2 recruitment measured a...More data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO cells co-expressing beta-arrestin2 assessed as beta-arrestin2 recruitment measured a...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Agonist activity at FLAG-tagged mouse mu opioid receptor expressed in human HEK293 cells assessed as inhibition of forskolin stimulated cAMP producti...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Agonist activity at FLAG-tagged mouse mu opioid receptor expressed in human HEK293 cells assessed as inhibition of forskolin stimulated cAMP producti...More data for this Ligand-Target Pair
Affinity DataEC50: 1.29E+3nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells co-expressing beta-arrestin2 assessed as beta-arrestin2 recruitment measured afte...More data for this Ligand-Target Pair
Affinity DataEC50: 1.27E+3nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells co-expressing beta-arrestin2 assessed as beta-arrestin2 recruitment measured afte...More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cell membrane measured after 90 mins by liquid scintillation counting met...More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cell membrane measured after 90 mins by liquid scintillation counting met...More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Displacement of [3H]-DPDPE from human delta opioid receptor expressed in CHO-K1 cells by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]-DPDPE from human delta opioid receptor expressed in CHO-K1 cells by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Binding affinity was determined towards Opioid receptor delta 1 in rat brain synaptosomes using [3H]deltorphin II as radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:The compound was tested for the ability to displace delta-receptor specific radioligand [3H]DPDPEMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cell membrane incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair