BDBM50000091 (6S,11R)-3-Cyclopropylmethyl-6-ethyl-8-hydroxy-11-methyl-3,4,5,6-tetrahydro-2H-2,6-methano-benzo[d]azocin-1-one::(6S,11R)-3-Cyclopropylmethyl-9-hydroxy-6,11-dimethyl-3,4,5,6-tetrahydro-2H-2,6-methano-benzo[d]azocin-1-one::3-Cyclopropylmethyl-6-ethyl-8-hydroxy-11-methyl-3,4,5,6-tetrahydro-2H-2,6-methano-benzo[d]azocin-1-one::3-Cyclopropylmethyl-6-ethyl-8-hydroxy-11-methyl-3,4,5,6-tetrahydro-2H-2,6-methano-benzo[d]azocin-1-one (ethylketocyclazocine)::3-Cyclopropylmethyl-6-ethyl-8-hydroxy-11-methyl-3,4,5,6-tetrahydro-2H-2,6-methano-benzo[d]azocin-1-one(Ethylketazocine, EKC)::CHEMBL279968::EKC::EKC(-)

SMILES CC[C@]12CCN(CC3CC3)C([C@@H]1C)C(=O)c1ccc(O)cc21

InChI Key

Data  35 KI  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 40 hits for monomerid = 50000091   

TargetDelta-type/Kappa-type/Mu-type opioid receptor(Human)
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataIC50: 5.90nMAssay Description:In vitro inhibitory activity against opioid receptor in Guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2019
Entry Details Article
PubMed
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataIC50: 8.40nMAssay Description:Ability to displace 50% of (+/-) ethylketocyclazocine (2.8) in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataEC50:  1.10nMAssay Description:Incorporation of [35S]GTP-gamma-S, into CHO membranes expressing human Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataEC50:  5.5nMAssay Description:Incorporation of [35S]- GTPgammaS into CHO membranes expressing human Opioid receptor mu 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataIC50: 47nMAssay Description:Ability to induce 50% of maximal effect in rabbit vas deferens expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  0.400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details
PubMed
TargetMu-type opioid receptor(Guinea pig)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  0.400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  0.570nMAssay Description:Binding affinity for the Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  0.620nMAssay Description:Binding affinity towards Opioid receptor kappa 1 in guinea pig brain membranes using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  0.620nMAssay Description:Binding affinity towards Opioid receptor kappa 1 by displacing the radioligand [3H]U-69593 from guinea pig brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  0.620nMAssay Description:Displacement of [3H]U-69593 from Opioid receptor kappa 1 of guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  0.620nMAssay Description:Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  0.620nMAssay Description:Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  0.620nMAssay Description:Binding affinity was determined towards opioid receptor kappa 1 using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  0.780nMAssay Description:Binding affinity was determined towards opioid receptor mu1 using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  0.780nMAssay Description:Binding affinity towards Opioid receptor mu 1 in guinea pig brain membranes using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  0.780nMAssay Description:Binding affinity towards Opioid receptor mu 1 by displacing the radioligand [3H]DAMGO from guinea pig brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  0.780nMAssay Description:Displacement of [3H]DAMGO from Opioid receptor mu 1 of guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  0.780nMAssay Description:Binding affinity towards Opioid receptor mu 1 from guinea pig brain using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  0.780nMAssay Description:Binding affinity against opioid receptor mu 1 using [3H]DAMGO as radioligand in guinea pig brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Targetkappa-type opioid receptor isoform 1(Western clawed frog)
Biological Research Center of Hungarian Academy of Sciences

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity for the Opioid receptor mu 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Pig)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
Targetkappa-type opioid receptor isoform 1(Western clawed frog)
Biological Research Center of Hungarian Academy of Sciences

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  2.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
Biological Research Center of Hungarian Academy of Sciences

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  2.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  3.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  3.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity against opioid receptor delta 1 using [3H]naltrindole as radioligand in guinea pig brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity towards Opioid receptor delta 1 from guinea pig brain using [3H]naltrindole as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]naltrindole from Opioid receptor delta 1 of guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity towards Opioid receptor delta 1 by displacing the radioligand [3H]naltrindole from guinea pig brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity towards Opioid receptor delta 1 in guinea pig brain membranes using [3H]naltrindole as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity was determined towards Opioid receptor delta 1 using [3H]naltrindole as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
Biological Research Center of Hungarian Academy of Sciences

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
Targetkappa-type opioid receptor isoform 1(Western clawed frog)
Biological Research Center of Hungarian Academy of Sciences

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  23nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
Biological Research Center of Hungarian Academy of Sciences

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  28.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataKi:  101nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details
PubMed