BDBM50559709 E-6005::E6005::Lotamilast::RVT-501

SMILES CNc1nc(-c2cccc(NC(=O)c3ccc(cc3)C(=O)OC)c2)c2cc(OC)c(OC)cc2n1

InChI Key InChIKey=BBTFKAOFCSOZMB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50559709   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50559709(Lotamilast | E-6005 | E6005 | RVT-501)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human U-937 cell derived PDE4 using [3H]-cAMP or [3H]-cGMP as substrate incubated for 60 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A [559-660](Human)
Guangdong Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50559709(Lotamilast | E-6005 | E6005 | RVT-501)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed