BDBM283996 E22::US10023564, Example 22

SMILES CCc1nc(CNC(=O)c2cc(ccc2F)C2NC(=O)NC(C)=C2C(=O)Nc2ccc3[nH]ncc3c2)no1

InChI Key InChIKey=XBRPSBXARPNOBH-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 283996   

TargetRhodopsin kinase GRK1(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM283996(US10023564, Example 22 | E22)
Affinity DataIC50: 3.50E+3nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
Go to US Patent

TargetBeta-adrenergic receptor kinase 1(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM283996(US10023564, Example 22 | E22)
Affinity DataIC50: 180nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
Go to US Patent

TargetG protein-coupled receptor kinase 5(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM283996(US10023564, Example 22 | E22)
Affinity DataIC50: 410nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
Go to US Patent

TargetRhodopsin kinase GRK1(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM283996(US10023564, Example 22 | E22)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of GRK1 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM283996(US10023564, Example 22 | E22)
Affinity DataIC50: 380nMAssay Description:Inhibition of GRK5 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM283996(US10023564, Example 22 | E22)
Affinity DataIC50: 160nMAssay Description:Inhibition of GRK2 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM283996(US10023564, Example 22 | E22)
Affinity DataIC50: 160nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetG protein-coupled receptor kinase 5(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM283996(US10023564, Example 22 | E22)
Affinity DataIC50: 380nMAssay Description:Inhibition of GRK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed