BDBM50542241 E127::ERYTHROSINE::US20230364057, Compound 253

SMILES Oc1c(I)cc2c(Oc3c(I)c(O)c(I)cc3C22OC(=O)c3ccccc23)c1I

InChI Key InChIKey=OALHHIHQOFIMEF-UHFFFAOYSA-N

Data  4 IC50  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50542241   

TargetNonstructural protein 3(ZIKV)
Australian National University

Curated by ChEMBL
LigandPNGBDBM50542241(E127 | ERYTHROSINE | US20230364057, Compound 253)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of Zika virus NS2B-NS3 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University

Curated by ChEMBL
LigandPNGBDBM50542241(E127 | ERYTHROSINE | US20230364057, Compound 253)
Affinity DataEC50:  600nMAssay Description:Inhibition of Zika virus NS2B-NS3 protease by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetFlavin reductase (NADPH)(Human)
Korea Basic Science Institute

Curated by ChEMBL
LigandPNGBDBM50542241(E127 | ERYTHROSINE | US20230364057, Compound 253)
Affinity DataKd:  160nMAssay Description:Binding affinity to human N-terminal His6-tagged and thrombin cleavage fused BLVRB expressed in Escherichia coli BL21 (DE3) assessed as dissociation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetFlavin reductase (NADPH)(Human)
Korea Basic Science Institute

Curated by ChEMBL
LigandPNGBDBM50542241(E127 | ERYTHROSINE | US20230364057, Compound 253)
Affinity DataKd:  158nMAssay Description:Binding affinity to human N-terminal His6-tagged and thrombin cleavage fused BLVRB expressed in Escherichia coli BL21 (DE3) assessed as dissociation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDNA gyrase inhibitor(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50542241(E127 | ERYTHROSINE | US20230364057, Compound 253)
Affinity DataIC50: 3.13E+3nMAssay Description:SDFQ HTS primary assay using pAB1_FL905 was performed in 2 µL of (1 xDNA gyrase buffer: 20 mM Tris-Acetate pH 7.9, 50 mM KAc, 10 mM MgCl2, 2 mM DTT, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 2(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50542241(E127 | ERYTHROSINE | US20230364057, Compound 253)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of 8-((4-chlorophenyl)amino)naphthalene-1-sulfonic acid binding to CDK2 (unknown origin) measured after 2 hrs by fluorescence based analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50542241(E127 | ERYTHROSINE | US20230364057, Compound 253)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of 8-((4-chlorophenyl)amino)naphthalene-1-sulfonic acid binding to CDK2 (unknown origin) incubated for 2 hrs in presence of staurosporine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed