BDBM50101086 CHEMBL20684::E-7010::N-(2-(4-hydroxyphenylamino)pyridin-3-yl)-4-methoxybenzenesulfonamide::N-[2-(4-Hydroxy-phenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide::N-{2-[(4-hydroxyphenyl)amino]pyridin-3-yl}-4-methoxybenzenesulfonamide

SMILES COc1ccc(cc1)S(=O)(=O)Nc2cccnc2Nc3ccc(cc3)O

InChI Key InChIKey=URCVCIZFVQDVPM-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50101086   

TargetTubulin alpha-1A chain(Pig)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50101086(E-7010 | N-{2-[(4-hydroxyphenyl)amino]pyridin-3-yl...)
Affinity DataIC50: 3.10E+3nMAssay Description:Concentration inhibiting tubulin polymerizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Eisai

Curated by ChEMBL
LigandPNGBDBM50101086(E-7010 | N-{2-[(4-hydroxyphenyl)amino]pyridin-3-yl...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibitory activity against tubulin polymerization.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Eisai

Curated by ChEMBL
LigandPNGBDBM50101086(E-7010 | N-{2-[(4-hydroxyphenyl)amino]pyridin-3-yl...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization measured every 30 secs for 30 mins by turbidimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTubulin beta chain(Pig)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50101086(E-7010 | N-{2-[(4-hydroxyphenyl)amino]pyridin-3-yl...)
Affinity DataIC50: 2.79E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization incubated for 60 mins by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed