BDBM50548283 C. i. mordant yellow 5::Dipentum::Olsalazine::US11744839, Compound of formula 2

SMILES OC(=O)c1cc(ccc1O)\N=N\c1ccc(O)c(c1)C(O)=O

InChI Key InChIKey=QQBDLJCYGRGAKP-UHFFFAOYSA-N

Data  1 IC50  3 Kd  1 ITC

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50548283   

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50548283(Olsalazine | C. i. mordant yellow 5 | Dipentum | U...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetFlavin reductase (NADPH)(Human)
Korea Basic Science Institute

Curated by ChEMBL
LigandPNGBDBM50548283(Olsalazine | C. i. mordant yellow 5 | Dipentum | U...)
Affinity DataKd:  70nMAssay Description:Binding affinity to human N-terminal His6-tagged and thrombin cleavage fused BLVRB expressed in Escherichia coli BL21 (DE3) assessed as dissociation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetFlavin reductase (NADPH)(Human)
Korea Basic Science Institute

Curated by ChEMBL
LigandPNGBDBM50548283(Olsalazine | C. i. mordant yellow 5 | Dipentum | U...)
Affinity DataKd:  71nMAssay Description:Binding affinity to human N-terminal His6-tagged and thrombin cleavage fused BLVRB expressed in Escherichia coli BL21 (DE3) assessed as dissociation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetFlavin reductase (NADPH)(Human)
Korea Basic Science Institute

Curated by ChEMBL
LigandPNGBDBM50548283(Olsalazine | C. i. mordant yellow 5 | Dipentum | U...)
Affinity DataKd:  70nMAssay Description:An enzyme activity assay for BLVRB was conducted. Since BLVRB catalyzes the NAD(P)H dependent readuction of FMN, changes in the NAD(P)H concentration...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2023
Entry Details
Go to US Patent

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 50548283   

CellFlavin reductase (NADPH)(Human)
Korea Basic Science Institute

US Patent
SyringePNGBDBM50548283(Olsalazine | C. i. mordant yellow 5 | Dipentum | U...)
ITC DataΔG°: -9.79kcal/mole −TΔS°: 0.00712kcal/mole ΔH°: -9.79kcal/mole logk: 1.53E+7
T: 25.00°C 
In DepthDetails
Go to US Patent