BDBM22883 CHEMBL12344::Dimaprit::[3-(carbamimidoylsulfanyl)propyl]dimethylamine

SMILES CN(C)CCCSC(N)=N

InChI Key InChIKey=OLHQOJYVQUNWPL-UHFFFAOYSA-N

Data  11 KI  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 22883   

TargetHistamine H2 receptor(Guinea pig)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM22883([3-(carbamimidoylsulfanyl)propyl]dimethylamine | C...)
Affinity DataKd:  2.63E+4nMAssay Description:Compound is evaluated for histamine H2 receptor agonistic activity in guinea pig cerebral cortex using [3H]tiotidine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22883([3-(carbamimidoylsulfanyl)propyl]dimethylamine | C...)
Affinity DataEC50:  1.59E+3nMAssay Description:Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22883([3-(carbamimidoylsulfanyl)propyl]dimethylamine | C...)
Affinity DataKi:  90nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22883([3-(carbamimidoylsulfanyl)propyl]dimethylamine | C...)
Affinity DataKi:  316nM ΔG°:  -9.22kcal/molepH: 7.4 T: 2°CAssay Description:Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22883([3-(carbamimidoylsulfanyl)propyl]dimethylamine | C...)
Affinity DataKi:  316nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22883([3-(carbamimidoylsulfanyl)propyl]dimethylamine | C...)
Affinity DataKi:  316nMAssay Description:Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22883([3-(carbamimidoylsulfanyl)propyl]dimethylamine | C...)
Affinity DataKi:  377nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
TargetHrh3 protein(Rat)
Schering-Plough Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM22883([3-(carbamimidoylsulfanyl)propyl]dimethylamine | C...)
Affinity DataKi:  440nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM22883([3-(carbamimidoylsulfanyl)propyl]dimethylamine | C...)
Affinity DataKi:  825nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM22883([3-(carbamimidoylsulfanyl)propyl]dimethylamine | C...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM22883([3-(carbamimidoylsulfanyl)propyl]dimethylamine | C...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22883([3-(carbamimidoylsulfanyl)propyl]dimethylamine | C...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22883([3-(carbamimidoylsulfanyl)propyl]dimethylamine | C...)
Affinity DataKi:  2.51E+4nMAssay Description:Displacement of [125I]iodoaminopotentidine from human histamine H2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed